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Changes of PACAP level in cerebrospinal fluid and plasma of patients with severe traumatic brain injury.

Abstract
PACAP has well-known neuroprotective potential including traumatic brain injury (TBI). Its level is up-regulated following various insults of the CNS in animal models. A few studies have documented alterations of PACAP levels in human serum. The time course of post-ictal PACAP levels, for example, show correlation with migraine severity. Very little is known about the course of PACAP levels following CNS injury in humans and the presence of PACAP has not yet been detected in cerebrospinal fluid (CSF) of subjects with severe TBI (sTBI). The aim of the present study was to determine whether PACAP occurs in the CSF and plasma (Pl) of patients that suffered sTBI and to establish a time course of PACAP levels in the CSF and Pl. Thirty eight subjects with sTBI were enrolled with a Glasgow Coma Scale ≤8 on admission. Samples were taken daily, until the time of death or for maximum 10 days. Our results demonstrated that PACAP was detectable in the CSF, with higher concentrations in patients with TBI. PACAP concentrations markedly increased in both Pl and CSF in the majority of patients 24-48h after the injury stayed high thereafter. In cases of surviving patients, Pl and CSF levels displayed parallel patterns, which may imply the damage of the blood-brain barrier. However, in patients, who died within the first week, Pl levels were markedly higher than CSF levels, possibly indicating the prognostic value of high Pl PACAP levels.
AuthorsPeter Bukovics, Endre Czeiter, Krisztina Amrein, Noemi Kovacs, Jozsef Pal, Andrea Tamas, Terez Bagoly, Zsuzsanna Helyes, Andras Buki, Dora Reglodi
JournalPeptides (Peptides) Vol. 60 Pg. 18-22 (Oct 2014) ISSN: 1873-5169 [Electronic] United States
PMID25017241 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2014 Elsevier Inc. All rights reserved.
Chemical References
  • Pituitary Adenylate Cyclase-Activating Polypeptide
Topics
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Brain Injuries (blood, cerebrospinal fluid)
  • Female
  • Humans
  • Injury Severity Score
  • Male
  • Middle Aged
  • Pituitary Adenylate Cyclase-Activating Polypeptide (blood, cerebrospinal fluid)
  • Young Adult

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