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Central nervous system infection caused by vancomycin-intermediate Staphylococcus aureus (SCCmec type IV, ST8).

Abstract
A 77-year-old Japanese man with a history of surgical treatment of chronic subdural hemorrhage was hospitalized for drainage of a subdural abscess and brain abscess in the right occipital area. Pus obtained from both the subdural abscess and brain abscess grew vancomycin-intermediate Staphylococcus aureus (VISA) (minimum inhibitory concentration = 4 μg/mL), which was confirmed by population analysis. The SCCmec type and sequence type were subsequently identified as IV and ST8, respectively. The VISA strains were both sensitive to levofloxacin, clindamycin, minocycline, and linezolid. The patient was successfully treated with linezolid and discharged on day 51 after admission. We herein describe the first reported case of a brain abscess and subdural abscess caused by VISA in Japan.
AuthorsHiroyoshi Kino, Hiromichi Suzuki, Tetsuo Yamaguchi, Shigeyuki Notake, Tsuyoshi Oishi, Yoshiro Ito, Kazuhiro Nakamura, Haruko Miyazaki, Tetsuya Matsumoto, Kazuya Uemura, Akira Matsumura
JournalJournal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy (J Infect Chemother) Vol. 20 Issue 10 Pg. 643-6 (Oct 2014) ISSN: 1437-7780 [Electronic] Netherlands
PMID25012468 (Publication Type: Case Reports, Journal Article)
CopyrightCopyright © 2014 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
Chemical References
  • Anti-Bacterial Agents
Topics
  • Aged
  • Anti-Bacterial Agents (therapeutic use)
  • Central Nervous System Infections (drug therapy, microbiology)
  • Humans
  • Male
  • Staphylococcal Infections (complications, drug therapy)
  • Staphylococcus aureus (classification, drug effects)
  • Vancomycin Resistance

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