COX-2 expression pattern is related to ovarian cancer differentiation and prognosis, but is not consistent with new model of pathogenesis.

Abstract

OBJECTIVE:

Numerous studies suggest that cyclooxygenase-2 (COX-2) is overexpressed in cancer. Our objective was to investigate the relationship between COX-2 expression in ovarian carcinoma and clinicopathological factors. An emphasis was put on the association with the new pattern of tumorigenesis that divides tumors into type I--less aggressive, and type II--more aggressive one. The prognostic significance of COX-2 expression was evaluated.

METHODS:

Ovarian cancer tissues were obtained from 65 patients in FIGO III stage (23 with type I and 42 with type II ovarian cancer). COX-2 expression was evaluated by immunohistochemistry. The statistical analysis was performed in order to assess the connection between COX-2 expression and characteristic factors of ovarian cancer patients as well as the new division for type I and type II ovarian cancer

RESULTS:

COX-2 expression was detected in 91% of tissue samples. It was markedly elevated in well differentiated tumors (p = 0.0041). The platinum-resistant tumors had significantly higher expression of COX-2 (p = 0.0337). There was no difference between COX-2 expression in type I and type II ovarian cancer (p = 0.6720). The COX-2 staining was not associated to age, CA125 level, the presence of ascites or any special histological type. An increased expression of COX-2 was an unfavorable prognostic factor for overall survival (p = 0.0369) and progression-free survival (p = 0.0218). Multivariate analysis confirmed that COX-2 overexpression is an independent unfavorable prognostic factor of shorter progression-free survival (p = 0.048).

CONCLUSIONS:

COX-2 expression is an unfavorable prognostic factor for progression-free survival and overall survival in ovarian cancer There is no relationship between COX-2 expression in ovarian cancer tissue and the examined model of ovarian cancer pathogenesis.

• Authors: Magdalena Magnowska, Mikołaj Zaborowski, Paweł Surowiak, Ewa Nowak-Markwitz, Maciej Zabel, Marek Spaczyński
• Journal: Ginekologia polska (Ginekol Pol) Vol. 85 Issue 5 Pg. 335-41 (May 2014) ISSN: 0017-0011 [Print] Poland
• PMID: 25011213 (Publication Type: Journal Article)

Chemical References

• Cyclooxygenase 2
• PTGS2 protein, human

Topics

• Cyclooxygenase 2 (genetics)
• Female
• Humans
• Immunohistochemistry (methods)
• Kaplan-Meier Estimate
• Models, Biological
• Neoplasm Invasiveness
• Neoplasm Staging
• Ovarian Neoplasms (genetics, mortality, pathology)
• Prognosis
• Proportional Hazards Models
• Survival Rate
• Women's Health