Abstract | BACKGROUND: MATERIALS AND METHODS: Preoperative serum CK19-2G2 levels were measured in 630 lung cancer patients and were compared with individuals with benign pulmonary diseases (nā=ā134) and healthy volunteers (nā=ā263). In 352 cases, the patients underwent surgery. In these patients, in addition to preoperative assays, serum CK19-2G2 was also monitored at 1 week and 1 month after the operation. RESULTS: The preoperative baseline levels of serum CK19-2G2 was significantly higher in lung cancer patients than patients with benign diseases and healthy controls (P<0.001). The postoperative levels of CK19-2G2 declined significantly within 1 week after tumor resection. Hereafter, a further decrease was observed in the patients who underwent palliative operations, while for the patients in the radical resection group, their CK19-2G2 levels stabilized. CONCLUSION:
|
Authors | Jia Gao, Fang Lv, Jia Li, Zongyong Wu, Jun Qi |
Journal | PloS one
(PLoS One)
Vol. 9
Issue 7
Pg. e101979
( 2014)
ISSN: 1932-6203 [Electronic] United States |
PMID | 25006982
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Antigens, Neoplasm
- Biomarkers, Tumor
- Keratin-19
- Peptide Fragments
- antigen CYFRA21.1
|
Topics |
- Adult
- Aged
- Aged, 80 and over
- Antigens, Neoplasm
(blood)
- Biomarkers, Tumor
(blood, chemistry)
- Female
- Humans
- Keratin-19
(blood, chemistry)
- Lung Neoplasms
(blood, pathology, surgery)
- Male
- Middle Aged
- Peptide Fragments
(blood)
- Treatment Outcome
- Young Adult
|