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Serum cytokeratin 19 fragment, CK19-2G2, as a newly identified biomarker for lung cancer.

AbstractBACKGROUND:
CK19-2G2, a new fragment of cytokeratin 19, is a potential tumor marker for diagnosing lung cancer. The preoperative level of serum CK19-2G2 has been demonstrated to be associated with tumor metastasis and survival of breast cancer patients. This study investigated the postoperative dynamic changes in serum CK19-2G2 levels and its clinical significance in lung cancer patients.
MATERIALS AND METHODS:
Preoperative serum CK19-2G2 levels were measured in 630 lung cancer patients and were compared with individuals with benign pulmonary diseases (nā€Š=ā€Š134) and healthy volunteers (nā€Š=ā€Š263). In 352 cases, the patients underwent surgery. In these patients, in addition to preoperative assays, serum CK19-2G2 was also monitored at 1 week and 1 month after the operation.
RESULTS:
The preoperative baseline levels of serum CK19-2G2 was significantly higher in lung cancer patients than patients with benign diseases and healthy controls (P<0.001). The postoperative levels of CK19-2G2 declined significantly within 1 week after tumor resection. Hereafter, a further decrease was observed in the patients who underwent palliative operations, while for the patients in the radical resection group, their CK19-2G2 levels stabilized.
CONCLUSION:
CK19-2G2 may be a candidate marker for diagnosing and monitoring a patient's response to lung cancer treatment. In addition, CK19-2G2 may be an indicator for micrometastases in lung cancer patients.
AuthorsJia Gao, Fang Lv, Jia Li, Zongyong Wu, Jun Qi
JournalPloS one (PLoS One) Vol. 9 Issue 7 Pg. e101979 ( 2014) ISSN: 1932-6203 [Electronic] United States
PMID25006982 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antigens, Neoplasm
  • Biomarkers, Tumor
  • Keratin-19
  • Peptide Fragments
  • antigen CYFRA21.1
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Antigens, Neoplasm (blood)
  • Biomarkers, Tumor (blood, chemistry)
  • Female
  • Humans
  • Keratin-19 (blood, chemistry)
  • Lung Neoplasms (blood, pathology, surgery)
  • Male
  • Middle Aged
  • Peptide Fragments (blood)
  • Treatment Outcome
  • Young Adult

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