HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Genetic polymorphisms of vein wall remodeling in chronic venous disease: a narrative and systematic review.

Abstract
Chronic venous disease encompasses a spectrum of disorders caused by an abnormal venous system. They include chronic venous insufficiency, varicose veins, lipodermatosclerosis, postthrombotic syndrome, and venous ulceration. Some evidence suggests a genetic predisposition to chronic venous disease from gene polymorphisms associated mainly with vein wall remodeling. The literature exploring these polymorphisms has not been reviewed and compiled thus far. In this narrative and systematic review, we present the current evidence available on the role of polymorphisms in genes involved in vein wall remodeling and other pathways as contributors to chronic venous disease. We searched the EMBASE, Medline, and PubMed databases from inception to 2013 for basic science or clinical studies relating to genetic associations in chronic venous disease and obtained 38 relevant studies for this review. Important candidate genes/proteins include the matrix metalloproteinases (extracellular matrix degradation), vascular endothelial growth factors (angiogenesis and vessel wall integrity), FOXC2 (vascular development), hemochromatosis (involved in venous ulceration and iron absorption), and various types of collagen (contributors to vein wall strength). The data on associations between these genes/proteins and the postthrombotic syndrome are limited and additional studies are required. These associations might have future prognostic and therapeutic implications.
AuthorsVighnesh Bharath, Susan R Kahn, Alejandro Lazo-Langner
JournalBlood (Blood) Vol. 124 Issue 8 Pg. 1242-50 (Aug 21 2014) ISSN: 1528-0020 [Electronic] United States
PMID25006132 (Publication Type: Journal Article, Review, Systematic Review)
Copyright© 2014 by The American Society of Hematology.
Chemical References
  • Forkhead Transcription Factors
  • VEGFA protein, human
  • Vascular Endothelial Growth Factor A
  • mesenchyme fork head 1 protein
  • Collagenases
Topics
  • Animals
  • Chronic Disease
  • Collagenases (genetics, metabolism)
  • Forkhead Transcription Factors (genetics, metabolism)
  • Genetic Predisposition to Disease
  • Humans
  • Polymorphism, Genetic
  • Postthrombotic Syndrome (genetics, metabolism, pathology)
  • PubMed
  • Varicose Ulcer (genetics, metabolism, pathology)
  • Vascular Endothelial Growth Factor A (genetics, metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: