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Strontium promotes cementoblasts differentiation through inhibiting sclerostin expression in vitro.

Abstract
Cementogenesis, performed by cementoblasts, is important for the repair of root resorption caused by orthodontic treatment. Based on recent studies, strontium has been applied for osteoporosis treatment due to its positive effect on osteoblasts. Although promising, the effect of strontium on cementoblasts is still unclear. So the aim of this research was to clarify and investigate the effect of strontium on cementogenesis via employing cementoblasts as model. A series of experiments including MTT, alkaline phosphatase activity, gene analysis, alizarin red staining, and western blot were carried out to evaluate the proliferation and differentiation of cementoblasts. In addition, expression of sclerostin was checked to analyze the possible mechanism. Our results show that strontium inhibits the proliferation of cementoblasts with a dose dependent manner; however, it can promote the differentiation of cementoblasts via downregulating sclerostin expression. Taking together, strontium may facilitate cementogenesis and benefit the treatment of root resorption at a low dose.
AuthorsXingfu Bao, Xianjun Liu, Yi Zhang, Yue Cui, Jindan Yao, Min Hu
JournalBioMed research international (Biomed Res Int) Vol. 2014 Pg. 487535 ( 2014) ISSN: 2314-6141 [Electronic] United States
PMID25003114 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Adaptor Proteins, Signal Transducing
  • Anthraquinones
  • Glycoproteins
  • Intercellular Signaling Peptides and Proteins
  • Ions
  • Sost protein, mouse
  • alizarin
  • Alkaline Phosphatase
  • Strontium
Topics
  • Adaptor Proteins, Signal Transducing
  • Alkaline Phosphatase (metabolism)
  • Animals
  • Anthraquinones (metabolism)
  • Calcification, Physiologic (drug effects, genetics)
  • Cell Differentiation (drug effects)
  • Cell Line
  • Cell Proliferation (drug effects)
  • Cell Shape (drug effects)
  • Dental Cementum (cytology, drug effects, enzymology, metabolism)
  • Fluorescent Antibody Technique
  • Gene Expression Regulation (drug effects)
  • Glycoproteins (genetics, metabolism)
  • Intercellular Signaling Peptides and Proteins
  • Ions
  • Mice
  • Real-Time Polymerase Chain Reaction
  • Staining and Labeling
  • Strontium (pharmacology)

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