Abstract | OBJECTIVE: MATERIALS AND METHODS: One hundred thirty eight women aged between 30 and 50 years with abnormal uterine bleeding and diagnosed as EH by transvaginal ultrasound were randomized to receive either LNG-IUD or dydrogesterone for 6 months. Primary outcome measures were regression of hyperplasia after 6 months of therapy. Secondary outcome measures were occurrence of side effects during treatment or recurrence of hyperplasia during follow-up period. RESULTS: After 6 months of treatment, regression of EH occurs in 96% of women in the levonorgestrel-releasing intrauterine system (LNG-IUS) group versus 80% of women in the oral group (P < .001). Adverse effects were relatively common with minimal differences between the 2 groups. Intermenstrual vaginal spotting and amenorrhea were more common in the LNG-IUD group (P value .01 and .0001). Patient satisfaction was significantly higher in the LNG-IUS group (P value .0001). Hysterectomy rates were lower in the LNG-IUS group than in the oral group (P = .001). Recurrence rate was 0% in the LNG-IUD group compared to 12.5% in the oral group. CONCLUSION: In management of EH without atypia, LNG-IUS achieves a higher regression and a lower hysterectomy rate than oral progesterone and could be used as a first-line therapy.
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Authors | Manal M El Behery, Hend S Saleh, Moustafa A Ibrahiem, Ebtesam M Kamal, Gamal A Kassem, Mohamed El Sayed Mohamed |
Journal | Reproductive sciences (Thousand Oaks, Calif.)
(Reprod Sci)
Vol. 22
Issue 3
Pg. 329-34
(Mar 2015)
ISSN: 1933-7205 [Electronic] United States |
PMID | 25001020
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
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Copyright | © The Author(s) 2014. |
Chemical References |
- Levonorgestrel
- Dydrogesterone
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Topics |
- Administration, Oral
- Adult
- Dydrogesterone
(administration & dosage, adverse effects)
- Egypt
- Endometrial Hyperplasia
(diagnosis, drug therapy)
- Endometrium
(diagnostic imaging, drug effects)
- Female
- Humans
- Hysterectomy
- Intrauterine Devices, Medicated
(adverse effects)
- Levonorgestrel
(administration & dosage, adverse effects)
- Middle Aged
- Patient Satisfaction
- Recurrence
- Remission Induction
- Time Factors
- Treatment Outcome
- Ultrasonography
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