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Albumin nanoparticles for the delivery of gabapentin: preparation, characterization and pharmacodynamic studies.

Abstract
The study was aimed to prepare and evaluate gabapentin loaded albumin nanoparticles and to find out their effectiveness in treating epilepsy. Albumin nanoparticles of gabapentin were prepared by pH-coacervation method. The drug was administered into animals as free drug, gabapentin bound with nanoparticles, and gabapentin bound with nanoparticles coated with polysorbate 80. The polysorbate 80 coated nanoparticles increased the gabapentin concentration in the brain about 3 fold in comparison with the free drug. Moreover, the polysorbate 80 coated nanoparticles significantly reduced the duration of all phases of convulsion in both maximal electroshock induced and pentylenetetrazole induced convulsion models in comparison with free drug and drug bound with nanoparticle formulations, which indicates the ability of polysorbate 80 coated nanoparticles to enhance the gabapentin concentration in the brain.
AuthorsBarnabas Wilson, Y Lavanya, S R B Priyadarshini, Muthu Ramasamy, Josephine Leno Jenita
JournalInternational journal of pharmaceutics (Int J Pharm) Vol. 473 Issue 1-2 Pg. 73-9 (Oct 01 2014) ISSN: 1873-3476 [Electronic] Netherlands
PMID24999053 (Publication Type: Journal Article)
CopyrightCopyright © 2014 Elsevier B.V. All rights reserved.
Chemical References
  • Amines
  • Anticonvulsants
  • Cyclohexanecarboxylic Acids
  • Drug Carriers
  • Polysorbates
  • Serum Albumin, Bovine
  • gamma-Aminobutyric Acid
  • Gabapentin
  • Pentylenetetrazole
Topics
  • Amines (administration & dosage, chemistry, pharmacokinetics)
  • Animals
  • Anticonvulsants (administration & dosage, chemistry, pharmacokinetics)
  • Brain (metabolism)
  • Cyclohexanecarboxylic Acids (administration & dosage, chemistry, pharmacokinetics)
  • Disease Models, Animal
  • Drug Carriers (administration & dosage, chemistry, pharmacokinetics)
  • Drug Compounding
  • Electroshock
  • Gabapentin
  • Male
  • Nanoparticles (administration & dosage, chemistry)
  • Pentylenetetrazole
  • Polysorbates (administration & dosage, chemistry, pharmacokinetics)
  • Rats, Wistar
  • Seizures (drug therapy)
  • Serum Albumin, Bovine (administration & dosage, chemistry, pharmacokinetics)
  • gamma-Aminobutyric Acid (administration & dosage, chemistry, pharmacokinetics)

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