Secondary hyperoxaluria: a risk factor for kidney stone formation and renal failure in native kidneys and renal grafts.

Abstract

Secondary hyperoxaluria is a multifactorial disease affecting several organs and tissues, among which stand native and transplanted kidneys. Nephrocalcinosis and nephrolithiasis may lead to renal insufficiency. Patients suffering from secondary hyperoxaluria, should be promptly identified and appropriately treated, so that less renal damage occurs. The aim of this review is to underline the causes of hyperoxaluria and the related pathophysiologic mechanisms, which are involved, along with the description of seven cases of irreversible renal graft injury due to secondary hyperoxaluria.

• Authors: Georgios Karaolanis, Sophia Lionaki, Demetrios Moris, Viktoria-Varvara Palla, Spiridon Vernadakis
• Journal: Transplantation reviews (Orlando, Fla.) (Transplant Rev (Orlando)) Vol. 28 Issue 4 Pg. 182-7 (Oct 2014) ISSN: 1557-9816 [Electronic] United States
• PMID: 24999029 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2014 Elsevier Inc. All rights reserved.

Topics

• Diagnosis, Differential
• Disease Progression
• Humans
• Hyperoxaluria (diagnosis, epidemiology, etiology, physiopathology)
• Kidney Calculi (epidemiology)
• Kidney Failure, Chronic (pathology)
• Kidney Transplantation
• Malabsorption Syndromes (complications)
• Renal Insufficiency (epidemiology)
• Risk Factors