HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Association study between interleukin-12 receptor β1/β2 genes and allergic rhinitis in the Chinese Han population.

Abstract
Interleukin-12 (IL-12) plays a key role in the protection against allergic reaction induced by allergen as well as the differentiation of T helper 1 cells in patients with allergic rhinitis (AR), exerting its biological effects through binding to specific IL-12 receptors (IL-12Rs) termed IL-12Rβ1 and IL-12Rβ2. In this study, we investigated the relationship between polymorphisms in the IL-12R gene and AR in the Chinese Han population. A total of 543 patients with AR and 749 normal controls were genotyped for IL-12Rβ1/rs438421, IL-12Rβ2/rs3790565, rs3790567, and rs6679356 using a PCR restriction fragment length polymorphism analysis. The association study of each polymorphism of the IL-12Rβ1 and IL-12Rβ2 gene and AR showed that a significantly increased prevalence of the homozygous rs438421 GG genotype and G allele appeared in the AR patients compared with healthy controls. A significantly decreased prevalence of AG in rs438421 in AR patients is compared with healthy controls. Our research demonstrated an important association between polymorphisms in IL-12Rβ1 and AR in the Chinese Han population. A strong association between rs438421 in a single nucleotide polymorphism of IL-12Rβ1 and AR was identified.
AuthorsPing Wei, Wei Kou, Rong Sun, Guo-Hua Hu, Di Hu, Jing Feng, Su-Ling Hong, Hou-Yong Kang
JournalEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery (Eur Arch Otorhinolaryngol) Vol. 272 Issue 4 Pg. 889-893 (Apr 2015) ISSN: 1434-4726 [Electronic] Germany
PMID24997981 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • IL12RB1 protein, human
  • IL12RB2 protein, human
  • Receptors, Interleukin-12
Topics
  • Adult
  • Alleles
  • Asian People
  • China
  • Female
  • Genetic Predisposition to Disease
  • Homozygote
  • Humans
  • Hypersensitivity (genetics)
  • Male
  • Middle Aged
  • Polymorphism, Restriction Fragment Length
  • Polymorphism, Single Nucleotide
  • Protective Factors
  • Receptors, Interleukin-12 (genetics)
  • Rhinitis, Allergic (genetics)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: