Abstract |
Interleukin-12 (IL-12) plays a key role in the protection against allergic reaction induced by allergen as well as the differentiation of T helper 1 cells in patients with allergic rhinitis (AR), exerting its biological effects through binding to specific IL-12 receptors (IL-12Rs) termed IL-12Rβ1 and IL-12Rβ2. In this study, we investigated the relationship between polymorphisms in the IL-12R gene and AR in the Chinese Han population. A total of 543 patients with AR and 749 normal controls were genotyped for IL-12Rβ1/rs438421, IL-12Rβ2/rs3790565, rs3790567, and rs6679356 using a PCR restriction fragment length polymorphism analysis. The association study of each polymorphism of the IL-12Rβ1 and IL-12Rβ2 gene and AR showed that a significantly increased prevalence of the homozygous rs438421 GG genotype and G allele appeared in the AR patients compared with healthy controls. A significantly decreased prevalence of AG in rs438421 in AR patients is compared with healthy controls. Our research demonstrated an important association between polymorphisms in IL-12Rβ1 and AR in the Chinese Han population. A strong association between rs438421 in a single nucleotide polymorphism of IL-12Rβ1 and AR was identified.
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Authors | Ping Wei, Wei Kou, Rong Sun, Guo-Hua Hu, Di Hu, Jing Feng, Su-Ling Hong, Hou-Yong Kang |
Journal | European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
(Eur Arch Otorhinolaryngol)
Vol. 272
Issue 4
Pg. 889-893
(Apr 2015)
ISSN: 1434-4726 [Electronic] Germany |
PMID | 24997981
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- IL12RB1 protein, human
- IL12RB2 protein, human
- Receptors, Interleukin-12
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Topics |
- Adult
- Alleles
- Asian People
- China
- Female
- Genetic Predisposition to Disease
- Homozygote
- Humans
- Hypersensitivity
(genetics)
- Male
- Middle Aged
- Polymorphism, Restriction Fragment Length
- Polymorphism, Single Nucleotide
- Protective Factors
- Receptors, Interleukin-12
(genetics)
- Rhinitis, Allergic
(genetics)
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