Abstract |
To assess the efficacy of low dose praziquantel regimens in comparison with standard 40 mg/kg dosing in the treatment of urinary schistosomiasis, a random allocation dose-finding trial was performed in children and adults from a Schistosoma haematobium endemic region in Coast Province, Kenya. Following an initial screening, 280 individuals with greater than or equal to 50 eggs/10 ml urine were randomly assigned to receive either 10, 20, 30, or 40 mg/kg of the drug in a single oral dose. Two to three months later, cure rates of 26%, 68%, 78%, and 84% were found for the 10, 20, 30, and 40 mg/kg doses, respectively. The results of 10 mg/kg oral dosing were significantly worse than for all other doses in terms of cure rate and of post-treatment prevalence of morbidity. The 40 mg/kg dosing resulted in a significantly higher cure rate than the 20 mg/kg doses; nevertheless, there was no significant difference between 20 mg/kg and 40 mg/kg doses in terms of mean post-treatment intensity of infection or post-treatment prevalence of hematuria or proteinuria. For large-scale control programs, oral 20 mg/kg praziquantel therapy for urinary schistosomiasis may prove as effective as the standard oral 40 mg/kg dosing for control of infection-associated morbidity and reduction of parasite transmission.
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Authors | C H King, D W Wiper 3rd, K V De Stigter, P A Peters, D Koech, J H Ouma, T K Arap Siongok, A A Mahmoud |
Journal | The American journal of tropical medicine and hygiene
(Am J Trop Med Hyg)
Vol. 40
Issue 5
Pg. 507-13
(May 1989)
ISSN: 0002-9637 [Print] United States |
PMID | 2499203
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Age Factors
- Aged
- Analysis of Variance
- Child
- Clinical Trials as Topic
- Dose-Response Relationship, Drug
- Female
- Follow-Up Studies
- Hematuria
(etiology)
- Humans
- Kenya
- Male
- Middle Aged
- Praziquantel
(administration & dosage, therapeutic use)
- Proteinuria
(etiology)
- Random Allocation
- Schistosomiasis haematobia
(complications, drug therapy)
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