Abstract |
Sphingolipids are crucial for the life of the cell. In land-dwelling mammals, they are equally important outside the cell-in the extracellular space of the skin barrier-because they prevent loss of water. Although a large body of research has elucidated many of the functions of sphingolipids, their extensive structural diversity remains intriguing. A new class of sphingolipids based on 6-hydroxylated sphingosine has recently been identified in human skin. Abnormal levels of these 6-hydroxylated ceramides have repeatedly been observed in atopic dermatitis; however, neither the biosynthesis nor the roles of these unique ceramide subclasses have been established in the human body. In this Minireview, we summarize the current knowledge of 6-hydroxyceramides, including their discovery, structure, stereochemistry, occurrence in healthy and diseased human epidermis, and synthetic approaches to 6-hydroxysphingosine and related ceramides.
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Authors | Andrej Kováčik, Jaroslav Roh, Kateřina Vávrová |
Journal | Chembiochem : a European journal of chemical biology
(Chembiochem)
Vol. 15
Issue 11
Pg. 1555-62
(Jul 21 2014)
ISSN: 1439-7633 [Electronic] Germany |
PMID | 24990520
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Copyright | © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Chemical References |
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Topics |
- Ceramides
(chemistry, metabolism)
- Humans
- Molecular Structure
- Sphingolipids
(chemistry, metabolism)
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