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The chemistry and biology of 6-hydroxyceramide, the youngest member of the human sphingolipid family.

Abstract
Sphingolipids are crucial for the life of the cell. In land-dwelling mammals, they are equally important outside the cell-in the extracellular space of the skin barrier-because they prevent loss of water. Although a large body of research has elucidated many of the functions of sphingolipids, their extensive structural diversity remains intriguing. A new class of sphingolipids based on 6-hydroxylated sphingosine has recently been identified in human skin. Abnormal levels of these 6-hydroxylated ceramides have repeatedly been observed in atopic dermatitis; however, neither the biosynthesis nor the roles of these unique ceramide subclasses have been established in the human body. In this Minireview, we summarize the current knowledge of 6-hydroxyceramides, including their discovery, structure, stereochemistry, occurrence in healthy and diseased human epidermis, and synthetic approaches to 6-hydroxysphingosine and related ceramides.
AuthorsAndrej Kováčik, Jaroslav Roh, Kateřina Vávrová
JournalChembiochem : a European journal of chemical biology (Chembiochem) Vol. 15 Issue 11 Pg. 1555-62 (Jul 21 2014) ISSN: 1439-7633 [Electronic] Germany
PMID24990520 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Copyright© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Chemical References
  • Ceramides
  • Sphingolipids
Topics
  • Ceramides (chemistry, metabolism)
  • Humans
  • Molecular Structure
  • Sphingolipids (chemistry, metabolism)

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