Does mirtazapine interfere with naturalistic diabetes treatment?

Abstract

Mirtazapine is known to induce weight gain and possibly leads to exacerbation of diabetic profiles. However, many cases of diabetic patients, who complained of insomnia and depression, were treated with mirtazapine in the clinical situations. Thus, this study aimed to assess any negative effects that treatment with mirtazapine may incur in diabetic patients.This study included 33 patients enrolled in naturalistic diabetes treatment that had also been diagnosed with depression and prescribed mirtazapine for at least 6 months. Another 33 diabetic patients who had not taken any psychiatric medicines were included as a control group. Body mass index, fasting plasma glucose, HbA1c, total cholesterol, triglyceride levels, high-density lipoprotein, and low-density lipoprotein were assessed at baseline, 3 months, and 6 months.The dose of mirtazapine at baseline was 24.3 ± 14.0 mg/d in the mirtazapine group, and the 2 groups did not differ in any baseline characteristics except for total cholesterol levels. Body mass index increased in both groups, and the change in the mirtazapine group (1.0 ± 0.6 kg/m) was significantly greater than that in the control group (0.3 ± 0.4 kg/m, P < 0.001) at 6 months. Only the control group exhibited a decrease in fasting plasma glucose, whereas both groups showed a decrease in HbA1c, low-density lipoprotein, and total cholesterol, an increase in high-density lipoprotein, and no change in triglyceride levels. None of the differences between the groups were statistically significant.In conclusion, mirtazapine increased the weight gain of diabetic patients; however, other diabetic and lipid markers generally did not worsen during the 6-month treatment period. These results suggest that, at least in the short term, mirtazapine is safe for diabetic patients in a stable state and are undergoing appropriate diabetic treatment.

• Authors: Hoo Rim Song, Young Sup Woo, Hee-Ryung Wang, In-Hee Shim, Tae-Youn Jun, Won-Myong Bahk
• Journal: Journal of clinical psychopharmacology (J Clin Psychopharmacol) Vol. 34 Issue 5 Pg. 588-94 (Oct 2014) ISSN: 1533-712X [Electronic] United States
• PMID: 24987796 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antidepressive Agents, Tricyclic
• Blood Glucose
• Glycated Hemoglobin A
• Triglycerides
• hemoglobin A1c protein, human
• Mianserin
• Cholesterol
• Mirtazapine

Topics

• Antidepressive Agents, Tricyclic (adverse effects)
• Blood Glucose (drug effects)
• Body Mass Index
• Case-Control Studies
• Cholesterol (blood)
• Diabetes Mellitus (blood, drug therapy)
• Dyslipidemias (blood, drug therapy)
• Female
• Glycated Hemoglobin (drug effects)
• Humans
• Male
• Mianserin (adverse effects, analogs & derivatives)
• Middle Aged
• Mirtazapine
• Retrospective Studies
• Triglycerides (blood)