Abstract |
Aberrant expression of human leukocyte antigens (HLA) class I has prognostic importance in various cancers. Here, we evaluated the prognostic value of classical (A/B/C) and nonclassical (G/E) HLA expression in 169 high grade epithelial ovarian cancer samples and linked that to clinicopathological characteristics and survival. Expression of HLA-A, -B/C, or -E was not correlated with survival. Survival was prolonged when tumours expressed HLA-G (P = 0.008) and HLA-G was an independent predictor for better survival (P = 0.011). In addition, HLA-G expression was associated with longer progression-free survival (P = 0.036) and response to chemotherapy (P = 0.014). Accordingly, high expression of HLA-G mRNA was associated with prolonged disease-free survival (P = 0.037) in 65 corresponding samples. Elevated serum-soluble HLA-G levels as measured by enzyme-linked immunosorbent assay in 50 matched patients were not correlated to HLA-G protein expression or gene expression nor with survival. During treatment, sHLA-G levels declined (P = 0.038). In conclusion, expression of HLA-G is an independent prognostic factor for improved survival in high grade epithelial ovarian cancer and a predictor for platinum sensitivity.
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Authors | M J Rutten, F Dijk, C D Savci-Heijink, M R Buist, G G Kenter, M J van de Vijver, E S Jordanova |
Journal | Journal of immunology research
(J Immunol Res)
Vol. 2014
Pg. 274584
( 2014)
ISSN: 2314-7156 [Electronic] Egypt |
PMID | 24987709
(Publication Type: Journal Article)
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Chemical References |
- HLA-G Antigens
- Histocompatibility Antigens Class I
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Biopsy
- Carcinoma, Ovarian Epithelial
- Disease Progression
- Female
- Follow-Up Studies
- HLA-G Antigens
(genetics, metabolism)
- Histocompatibility Antigens Class I
(genetics, metabolism)
- Humans
- Middle Aged
- Neoplasm Grading
- Neoplasm Recurrence, Local
- Neoplasm Staging
- Neoplasms, Glandular and Epithelial
(genetics, mortality, pathology, therapy)
- Ovarian Neoplasms
(genetics, mortality, pathology, therapy)
- Prognosis
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