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HLA-G expression is an independent predictor for improved survival in high grade ovarian carcinomas.

Abstract
Aberrant expression of human leukocyte antigens (HLA) class I has prognostic importance in various cancers. Here, we evaluated the prognostic value of classical (A/B/C) and nonclassical (G/E) HLA expression in 169 high grade epithelial ovarian cancer samples and linked that to clinicopathological characteristics and survival. Expression of HLA-A, -B/C, or -E was not correlated with survival. Survival was prolonged when tumours expressed HLA-G (P = 0.008) and HLA-G was an independent predictor for better survival (P = 0.011). In addition, HLA-G expression was associated with longer progression-free survival (P = 0.036) and response to chemotherapy (P = 0.014). Accordingly, high expression of HLA-G mRNA was associated with prolonged disease-free survival (P = 0.037) in 65 corresponding samples. Elevated serum-soluble HLA-G levels as measured by enzyme-linked immunosorbent assay in 50 matched patients were not correlated to HLA-G protein expression or gene expression nor with survival. During treatment, sHLA-G levels declined (P = 0.038). In conclusion, expression of HLA-G is an independent prognostic factor for improved survival in high grade epithelial ovarian cancer and a predictor for platinum sensitivity.
AuthorsM J Rutten, F Dijk, C D Savci-Heijink, M R Buist, G G Kenter, M J van de Vijver, E S Jordanova
JournalJournal of immunology research (J Immunol Res) Vol. 2014 Pg. 274584 ( 2014) ISSN: 2314-7156 [Electronic] Egypt
PMID24987709 (Publication Type: Journal Article)
Chemical References
  • HLA-G Antigens
  • Histocompatibility Antigens Class I
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Biopsy
  • Carcinoma, Ovarian Epithelial
  • Disease Progression
  • Female
  • Follow-Up Studies
  • HLA-G Antigens (genetics, metabolism)
  • Histocompatibility Antigens Class I (genetics, metabolism)
  • Humans
  • Middle Aged
  • Neoplasm Grading
  • Neoplasm Recurrence, Local
  • Neoplasm Staging
  • Neoplasms, Glandular and Epithelial (genetics, mortality, pathology, therapy)
  • Ovarian Neoplasms (genetics, mortality, pathology, therapy)
  • Prognosis

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