HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Lysophospholipid acyltransferases mediate phosphatidylcholine diversification to achieve the physical properties required in vivo.

Abstract
The acyl-chain composition of the major mammalian phospholipid phosphatidylcholine (PC) is distinct in various tissues. Although it was classically suggested that PC diversity is acquired through acyl-chain remodeling, the mechanisms and biological relevance of acyl-chain diversity remain unclear. Here, we show that differences in the substrate selectivity of lysophospholipid acyltransferases regulate tissue PC acyl-chain composition through contribution of both the de novo and remodeling pathways, depending on the fatty acid species. Unexpectedly, while dipalmitoyl-PC (DPPC) is enriched through the remodeling pathway, several polyunsaturated PC molecules accumulate during the de novo pathway. We confirmed this concept for DPPC in pulmonary surfactant and showed that the biophysical properties of this lipid are important to prevent the early onset of acute lung injury. We propose a model of harmonized processes for phospholipid diversification to satisfy in vivo requirements, with an example of its biological relevance.
AuthorsTakeshi Harayama, Miki Eto, Hideo Shindou, Yoshihiro Kita, Eiji Otsubo, Daisuke Hishikawa, Satoshi Ishii, Kenji Sakimura, Masayoshi Mishina, Takao Shimizu
JournalCell metabolism (Cell Metab) Vol. 20 Issue 2 Pg. 295-305 (Aug 05 2014) ISSN: 1932-7420 [Electronic] United States
PMID24981836 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2014 Elsevier Inc. All rights reserved.
Chemical References
  • Chemokines
  • Cytokines
  • Phosphatidylcholines
  • Surface-Active Agents
  • 1,2-Dipalmitoylphosphatidylcholine
  • 1-Acylglycerophosphocholine O-Acyltransferase
  • 1-palmitoyl-2-oleoylphosphatidylcholine
Topics
  • 1,2-Dipalmitoylphosphatidylcholine (analysis, metabolism)
  • 1-Acylglycerophosphocholine O-Acyltransferase (genetics, metabolism)
  • Animals
  • CHO Cells
  • Chemokines (genetics, metabolism)
  • Cricetinae
  • Cricetulus
  • Cytokines (genetics, metabolism)
  • Lung Injury (etiology, metabolism)
  • Mice
  • Mice, Inbred C57BL
  • Phosphatidylcholines (analysis, metabolism)
  • Surface-Active Agents (chemistry)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: