Relapsing polymyositis in chronic graft versus host disease.

Abstract

Chronic graft versus host disease (GVHD) is a major complication of allogeneic hematopoietic stem cell transplantation, which contributes to the morbidity and mortality of transplant patients. A polymyositis pattern of injury is a rare manifestation of chronic GVHD in skeletal muscle after hematopoietic stem cell transplantation. We report a 54-year-old man with acute myeloid lymphoma who underwent an allogeneic bone marrow transplantation and subsequently developed acute gastrointestinal GVHD 2 months post-transplantation and polymyositis 14 months post-transplantation. Upon tapering of steroids, the patient experienced a relapse of polymyositis. The literature on polymyositis in chronic GVHD is briefly reviewed.

• Authors: Nematullah Sharaf, Richard A Prayson
• Journal: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia (J Clin Neurosci) Vol. 21 Issue 11 Pg. 1964-5 (Nov 2014) ISSN: 1532-2653 [Electronic] Scotland
• PMID: 24980629 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2014 Elsevier Ltd. All rights reserved.

Chemical References

• Adrenal Cortex Hormones

Topics

• Adrenal Cortex Hormones (administration & dosage)
• Chronic Disease
• Graft vs Host Disease (complications, etiology)
• Hematopoietic Stem Cell Transplantation (adverse effects)
• Humans
• Male
• Middle Aged
• Polymyositis (drug therapy, etiology, immunology)
• Recurrence
• Transplantation, Homologous