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Health assessment of gasoline and fuel oxygenate vapors: developmental toxicity in mice.

Abstract
CD-1 mice were exposed to baseline gasoline vapor condensate (BGVC) alone or to vapors of gasoline blended with methyl tertiary butyl ether (G/MTBE). Inhalation exposures were 6h/d on GD 5-17 at levels of 0, 2000, 10,000, and 20,000mg/m(3). Dams were evaluated for evidence of maternal toxicity, and fetuses were weighed, sexed, and evaluated for external, visceral, and skeletal anomalies. Exposure to 20,000mg/m(3) of BGVC produced slight reductions in maternal body weight/gain and decreased fetal body weight. G/MTBE exposure did not produce statistically significant maternal or developmental effects; however, two uncommon ventral wall closure defects occurred: gastroschisis (1 fetus at 10,000mg/m(3)) and ectopia cordis (1 fetus at 2000mg/m(3); 2 fetuses/1 litter at 10,000mg/m(3)). A second study (G/MTBE-2) evaluated similar exposure levels on GD 5-16 and an additional group exposed to 30,000mg/m(3) from GD 5-10. An increased incidence of cleft palate was observed at 30,000mg/m(3) G/MTBE. No ectopia cordis occurred in the replicate study, but a single observation of gastroschisis was observed at 30,000mg/m(3). The no observed adverse effect levels for maternal/developmental toxicity in the BGVC study were 10,000/2000mg/m(3), 20,000/20,000 for the G/MTBE study, and 10,000/20,000 for the G/MTBE-2 study.
AuthorsL G Roberts, T M Gray, M C Marr, R W Tyl, G W Trimmer, G M Hoffman, F J Murray, C R Clark, C A Schreiner
JournalRegulatory toxicology and pharmacology : RTP (Regul Toxicol Pharmacol) Vol. 70 Issue 2 Suppl Pg. S58-68 (Nov 2014) ISSN: 1096-0295 [Electronic] Netherlands
PMID24979735 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.
Chemical References
  • Air Pollutants
  • Gasoline
Topics
  • Air Pollutants (toxicity)
  • Animals
  • Female
  • Fetal Development (drug effects)
  • Gasoline (toxicity)
  • Inhalation
  • Male
  • Mice
  • Risk Assessment
  • Toxicity Tests

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