J-aggregates of organic dye molecules complexed with iron oxide nanoparticles for imaging-guided photothermal therapy under 915-nm light.

Abstract

Recently, the development of nano-theranostic agents aiming at imaging guided therapy has received great attention. In this work, a near-infrared (NIR) heptamethine indocyanine dye, IR825, in the presence of cationic polymer, polyallylamine hydrochloride (PAH), forms J-aggregates with red-shifted and significantly enhanced absorbance. After further complexing with ultra-small iron oxide nanoparticles (IONPs) and the followed functionalization with polyethylene glycol (PEG), the obtained IR825@PAH-IONP-PEG composite nanoparticles are highly stable in different physiological media. With a sharp absorbance peak, IR825@PAH-IONP-PEG can serve as an effective photothermal agent under laser irradiation at 915 nm, which appears to be optimal in photothermal therapy application considering its improved tissue penetration compared with 808-nm light and much lower water heating in comparison to 980-nm light. As revealed by magnetic resonance (MR) imaging, those nanoparticles after intravenous injection exhibit high tumor accumulation, which is then harnessed for in vivo photothermal ablation of tumors, achieving excellent therapeutic efficacy in a mouse tumor model. This study demonstrates for the first time that J-aggregates of organic dye molecules are an interesting class of photothermal material, which when combined with other imageable nanoprobes could serve as a theranostic agent for imaging-guided photothermal therapy of cancer.

• Authors: Xuejiao Song, Hua Gong, Teng Liu, Liang Cheng, Chao Wang, Xiaoqi Sun, Chao Liang, Zhuang Liu
• Journal: Small (Weinheim an der Bergstrasse, Germany) (Small) Vol. 10 Issue 21 Pg. 4362-70 (Nov 12 2014) ISSN: 1613-6829 [Electronic] Germany
• PMID: 24976309 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Coloring Agents
• Ferric Compounds
• ferric oxide
• Polyethylene Glycols

Topics

• Animals
• Cells, Cultured
• Chemical Precipitation
• Coloring Agents (chemistry)
• Ferric Compounds (chemistry)
• Humans
• Hyperthermia, Induced (instrumentation, methods)
• Light
• Magnetic Resonance Imaging (instrumentation, methods)
• Metal Nanoparticles (chemistry)
• Mice
• Mice, Inbred BALB C
• Phototherapy (instrumentation, methods)
• Polyethylene Glycols (chemistry)
• U937 Cells
• Xenograft Model Antitumor Assays