HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Inhibition of DMBA-induced mammary tumorigenesis by caloric restriction in rats fed high-fat diets.

Abstract
Most previous studies on the inhibiting effect of caloric restriction during promotion of DMBA-induced mammary carcinogenesis have used low to moderate levels of dietary fat, i.e., about 4 to 14% by weight. The current study was designed to test whether a moderate degree of caloric restriction, 25%, would inhibit tumor growth in rats fed the equivalent of 20% dietary fat which approximates human consumption in affluent countries. Rats were fed diets ad libitum that contained 5, 15 or 20% corn oil. Groups of rats were pair-fed to the last 2 groups, but subjected to a 25% caloric restriction. These groups were fed 20 or 26.7% corn oil so that absolute fat intake in the paired groups was identical. Significant inhibition of tumor incidence, tumor weight, tumor burden, body fat deposition, and fasting serum insulin were observed in the 2 calorically restricted groups. We conclude that moderate caloric restriction is significantly more effective in inhibiting tumor growth than is the promoting effect of diets high in fat. Total body weight, body fat and serum insulin concentrations may be better correlates of risk of developing mammary tumors than is dietary fat.
AuthorsD M Klurfeld, C B Welch, L M Lloyd, D Kritchevsky
JournalInternational journal of cancer (Int J Cancer) Vol. 43 Issue 5 Pg. 922-5 (May 15 1989) ISSN: 0020-7136 [Print] United States
PMID2497075 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Blood Glucose
  • Dietary Fats
  • Hydroxybutyrates
  • Insulin
  • 9,10-Dimethyl-1,2-benzanthracene
  • 3-Hydroxybutyric Acid
Topics
  • 3-Hydroxybutyric Acid
  • 9,10-Dimethyl-1,2-benzanthracene
  • Animals
  • Blood Glucose (metabolism)
  • Diet, Reducing
  • Dietary Fats (administration & dosage)
  • Female
  • Hydroxybutyrates (blood)
  • Insulin (blood)
  • Mammary Neoplasms, Experimental (pathology, prevention & control)
  • Rats
  • Rats, Inbred Strains

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: