Abstract | OBJECTIVE: METHODS: The study population included 65 newly diagnosed Israeli MBC patients. Clinical and pathologic data were collected at the time of referral. Pathologic examinations were conducted at the pathology departments of the referring centers. The RS assay (Oncotype DX™) was performed on paraffin-embedded tumor samples at Genomic Health laboratories. RESULTS: The mean age of the patients was 65.1 years (range 38-88 years). Low-risk (RS<18), intermediate-risk (RS 18-30) and high-risk (RS≥31) scores were noted in 29 patients (44.6%), 27 patients (41.5%) and 9 patients (13.9%), respectively. The distribution of RS in male patients was similar to the distribution in 2,455 female patients from Israel referred during the same time period. CONCLUSION: Our data suggest that the distribution of Oncotype DX RS in ER-positive MBC patients is similar to that of female breast cancer patients.
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Authors | Tal Grenader, Rinat Yerushalmi, Margarita Tokar, Georgeta Fried, Bella Kaufman, Tamar Peretz, David B Geffen |
Journal | Oncology
(Oncology)
Vol. 87
Issue 1
Pg. 1-6
( 2014)
ISSN: 1423-0232 [Electronic] Switzerland |
PMID | 24970679
(Publication Type: Journal Article)
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Copyright | © 2014 S. Karger AG, Basel. |
Chemical References |
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Breast Neoplasms, Male
(genetics, metabolism, pathology)
- Female
- Humans
- Israel
- Male
- Middle Aged
- Neoplasm Recurrence, Local
(genetics, metabolism)
- Proportional Hazards Models
- Receptors, Estrogen
(metabolism)
- Risk
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