Comparison of tolterodine with standard treatment in pediatric patients with non-neurogenic dysfunctional voiding/over active bladder: a systematic review.

Abstract

To examine the efficacy, safety and tolerability of tolterodine in children with overactive bladder in comparison with standard treatment i.e. oxybutynin as demonstrated in randomized clinical trials and other studies. A systematic search was done to screen the studies evaluating the effect of tolterodine in children with non-neurogenic overactive bladder. Results of studies were pooled and compared. Efficacy was determined from micturition diaries and dysfunctional voiding symptoms score. Safety and tolerability were assessed from the reported treatment emergent adverse events. A total of six randomized clinical trials and 11 other studies of tolterodine in children with urinary incontinence were included in the present systematic review. The dose of tolterodine used in different settings ranged from '0.5 to 8 mg/day' instead of '0.5 to 8 mg/kg per day' and the duration of studies ranged from 2 weeks to 12 months. Both extended and immediate release preparations of tolterodine were shown to have comparable efficacy and tolterodine proved to have comparable efficacy with better tolerability than oxybutynin in these studies. It can be concluded that tolterodine is efficacious in treatment of urinary incontinence in children. Moreover, its efficacy is comparable to oxybutynin, the most commonly prescribed anticholinergic in this condition, while having better tolerability. Hence, it can be considered as first line therapy for the treatmentof urinary incontinence in children.

• Authors: B Medhi, N Mittal, D Bansal, A Prakash, S C Sarangi, B Nirthi
• Journal: Indian journal of physiology and pharmacology (Indian J Physiol Pharmacol) 2013 Oct-Dec Vol. 57 Issue 4 Pg. 343-53 ISSN: 0019-5499 [Print] India
• PMID: 24968572 (Publication Type: Journal Article, Review, Systematic Review)

Chemical References

• Benzhydryl Compounds
• Cresols
• Mandelic Acids
• Muscarinic Antagonists
• Urological Agents
• Phenylpropanolamine
• Tolterodine Tartrate
• oxybutynin

Topics

• Adolescent
• Age Factors
• Benzhydryl Compounds (administration & dosage, adverse effects, therapeutic use)
• Child
• Cresols (administration & dosage, adverse effects, therapeutic use)
• Humans
• Mandelic Acids (administration & dosage, adverse effects, therapeutic use)
• Muscarinic Antagonists (administration & dosage, adverse effects, therapeutic use)
• Phenylpropanolamine (administration & dosage, adverse effects, therapeutic use)
• Tolterodine Tartrate
• Treatment Outcome
• Urinary Bladder (drug effects, physiopathology)
• Urinary Bladder, Overactive (diagnosis, drug therapy, physiopathology)
• Urinary Incontinence (diagnosis, drug therapy, physiopathology)
• Urological Agents (administration & dosage, adverse effects, therapeutic use)