Abstract | PURPOSE: To examine whether an estimated trans-lamina cribrosa pressure difference (TLCPD) better than intraocular pressure (IOP) correlated with markers for glaucoma. METHODS: The population-based Beijing Eye Study 2011 included 3468 individuals. Cerebrospinal fluid pressure (CSFP) was calculated as CSFP [mmHg] = 0.44 × Body Mass Index [kg/m(2) ] + 0.16 × Diastolic Blood Pressure [mmHg] - 0.18 × Age [Years] - 1.91. TLCPD was IOP-CSFP. RESULTS: In the non-glaucomatous population, mean TLCPD was 5.8 ± 4.1 mmHg and mean estimated CSFP was 8.9 ± 3.7 mmHg. IOP was higher (p = 0.008), CSFP was lower (p < 0.001), and TLCPD was (p < 0.001) higher in the glaucoma group than in the non-glaucomatous group. The intergroup difference was highest for TLCPD (2.1 mmHg) followed by CSFP (1.7 mmHg) and IOP (0.4 mmHg). Open-angle glaucoma (OAG) was associated with higher TLCPD [p < 0.001; odds ratio (OR): 1.14; 95% confidence intervals (CI): 1.08, 1.19] but not with IOP (p = 0.22; OR: 0.96; 95% CI: 0.89, 1.03). In contrast, angle-closure glaucoma ( ACG) was associated with higher IOP (p = 0.03; B: 0.14; OR: 1.15; 95% CI: 1.01, 1.30) but not with TLCPD (p = 0.98), after adjustment for age and anterior chamber depth. Retinal nerve fibre layer thickness was associated with lower TLCPD (p = 0.036) but not with IOP (p = 0.96), after adjusting for gender, age, region of habitation, optic disc area and refractive error. Neuroretinal area and volume were associated with smaller TLCPD (p = 0.002, and p < 0.001, respectively), after adjusting for gender, optic disc area and refractive error, but not with IOP (p = 0.43 and p = 0.25, resp.). CONCLUSIONS: In OAG, but not in ACG, calculated TLCPD versus IOP showed a better association with glaucoma presence and amount of glaucomatous optic neuropathy. It supports the notion of a potential role of low CSFP in the pathogenesis of OAG.
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Authors | Jost B Jonas, Ning Li Wang, Ya Xing Wang, Qi Sheng You, Xiao Bin Xie, Di Ya Yang, Liang Xu |
Journal | Acta ophthalmologica
(Acta Ophthalmol)
Vol. 93
Issue 1
Pg. e7-e13
(Feb 2015)
ISSN: 1755-3768 [Electronic] England |
PMID | 24961652
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2014 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd. |
Chemical References |
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Topics |
- Aged
- Aged, 80 and over
- Biomarkers
- Blood Pressure
(physiology)
- Body Mass Index
- Cerebrospinal Fluid Pressure
(physiology)
- Female
- Glaucoma, Angle-Closure
(diagnosis, physiopathology)
- Glaucoma, Open-Angle
(diagnosis, physiopathology)
- Humans
- Intraocular Pressure
(physiology)
- Male
- Middle Aged
- Optic Disk
(physiology)
- Tonometry, Ocular
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