Prolactin serum levels correlate with inflammatory status in drug-naïve first-episode schizophrenia.

Abstract

OBJECTIVES:

The present study was to examine the relationship between serum levels of prolactin and the inflammatory status in drug-naïve, first-episode schizophrenia patients with normal weight.

METHODS:

Patients with normal weight, drug-naïve, first-episode schizophrenia and healthy controls were enrolled in the study. Serum levels of prolactin (PRL) were measured using electrical chemiluminescence immunoassay. Serum levels of interleukin-1β (IL-1β), tumour necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were examined using enzyme-linked immunosorbent assay (ELISA).

RESULTS:

Sixty patients with normal weight, drug-naïve, first-episode schizophrenia and 60 healthy controls were enrolled. The schizophrenia group had higher serum levels of PRL, IL-1β, IL-6 and TNF-α compared with the control group. There was a gender difference of hyperprolactinemia in schizophrenia group. There were positive relationships between serum levels of PRL and serum levels of IL-1β, IL-6 and TNF-α within the schizophrenia group. Within the schizophrenia group, TNF-α was the strongest predictor among the three cytokines for serum levels of prolactin after controlling for gender, age, education, smoking status and disease duration.

CONCLUSIONS:

Patients with normal weight, drug-naïve, first-episode schizophrenia present elevated serum levels of PRL, which might be related to the up-regulated inflammatory status in this patient population.

• Authors: Xueqin Song, Xiaoduo Fan, Jianjiang Zhang, Hui Zheng, Xue Li, Lijuan Pang, Xumei Chen, Wei Zhang, Amy Harrington, Douglas Ziedonis, Luxian Lv
• Journal: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry (World J Biol Psychiatry) Vol. 15 Issue 7 Pg. 546-52 (Sep 2014) ISSN: 1814-1412 [Electronic] England
• PMID: 24959913 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cytokines
• Interleukin-1beta
• Interleukin-6
• Tumor Necrosis Factor-alpha
• Prolactin

Topics

• Adult
• Cytokines (blood)
• Female
• Humans
• Hyperprolactinemia (blood)
• Inflammation (blood)
• Interleukin-1beta (blood)
• Interleukin-6 (blood)
• Male
• Prolactin (blood)
• Schizophrenia (blood)
• Tumor Necrosis Factor-alpha (blood)
• Young Adult