HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

GnRH agonist triggers and their use in assisted reproductive technology: the past, the present and the future.

Abstract
Gonadotropin releasing hormone agonist triggers are very effective in eliminating early-onset ovarian hyperstimulation syndrome (OHSS). However, in most studies they result in inferior pregnancy rates compared to hCG triggers in fresh autologous transfers. This is not due to an effect on embryo quality but rather due to inadequate corpus luteum formation and a defective luteal phase causing poor implantation. Intensive and adjusted steroid support or low-dose hCG may correct this. Late-onset OHSS is eliminated by using a freeze-all strategy. Pregnancy rates after transfer of thawed vitrified embryos are consistently high. A strategy combining a gonadotropin releasing hormone agonist trigger with vitrification of all embryos has been proposed as a means of achieving a truly OHSS-free clinic.
AuthorsPaul Atkinson, Juliette Koch, Daniella Susic, William L Ledger
JournalWomen's health (London, England) (Womens Health (Lond)) Vol. 10 Issue 3 Pg. 267-76 (May 2014) ISSN: 1745-5065 [Electronic] United States
PMID24956293 (Publication Type: Journal Article, Review)
Chemical References
  • Fertility Agents, Female
  • Gonadotropin-Releasing Hormone
Topics
  • Corpus Luteum (drug effects)
  • Dose-Response Relationship, Drug
  • Female
  • Fertility Agents, Female (administration & dosage, adverse effects)
  • Fertilization in Vitro (adverse effects)
  • Gonadotropin-Releasing Hormone (agonists)
  • Humans
  • Infertility, Female (drug therapy)
  • Ovarian Hyperstimulation Syndrome (prevention & control)
  • Ovary (drug effects)
  • Ovulation Induction (adverse effects, methods)
  • Pregnancy
  • Pregnancy Rate
  • Prognosis

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: