Abstract |
One of the hallmarks in the advancement of cancer cells is an ability to overcome and acquire resistance to adverse conditions. There has been a large amount of cancer research on IGFBP-3 as a pro-apoptotic molecule in vitro. These pro-apoptotic properties, however, do not correlate with several studies linking high IGFBP-3 levels in breast cancer tissue to rapid growth and poor prognosis. Evidence is emerging that IGFBP-3 also exhibits pro-survival and growth-promoting properties in vitro. How IGFBP-3 pivots cell fate to either death or survival, it seems, comes down to a complex interplay between cells' microenvironments and the presence of cellular IGFBP-3 binding partners and growth factor receptors. The cytoprotective actions of IGFBP-3 are not restricted to cancer but are also observed in other disease states, such as retinopathy and brain ischaemia. Here we review the literature on this paradoxical nature of IGFBP-3, its pro-apoptotic and growth-inhibitory actions versus its cytoprotective and growth-potentiating properties, and discuss the implications of targeting IGFBP-3 for treatment of disease.
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Authors | Michael A Johnson, Sue M Firth |
Journal | Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
(Growth Horm IGF Res)
Vol. 24
Issue 5
Pg. 164-73
(Oct 2014)
ISSN: 1532-2238 [Electronic] Scotland |
PMID | 24953254
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Copyright | Copyright © 2014 Elsevier Ltd. All rights reserved. |
Chemical References |
- IGFBP3 protein, human
- Insulin-Like Growth Factor Binding Protein 3
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Topics |
- Animals
- Apoptosis
(genetics)
- Cell Differentiation
(genetics)
- Cell Proliferation
(genetics)
- Disease
(genetics)
- Endoplasmic Reticulum
(metabolism)
- Genes, Switch
- Humans
- Insulin-Like Growth Factor Binding Protein 3
(physiology)
- Neoplasms
(genetics)
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