Comparison of muscle paralysis after intravenous and intraosseous administration of succinylcholine in Swine.

Abstract

AIM:

To compare the onset and duration of intravenous (IV) and intraosseous (IO) administration of succinylcholine in swine.

METHODS:

Electromyographic (EMG) amplitudes were used to characterize muscle paralysis following administration of succinylcholine via the IV or IO route in four Yorkshire-cross swine.

RESULTS:

The onset of action of succinylcholine was statistically longer after IO administration (0.97±0.40) compared with IV administration (0.55±0.26) (p=.048). Duration of action was unaffected by route of administration: IO, 11.4±4.2, and IV, 12.9±3.8 (p=.65).

CONCLUSIONS:

Succinylcholine can be effectively administered via the IO route. However, an increased dose may be necessary when administering succinylcholine via the IO route to achieve the same rapid onset as standard IV dosing.

• Authors: Michael J Loughren, James Kilbourn, Kevin Worth, James Burgert, Brian Gegel, Don Johnson
• Journal: Journal of special operations medicine : a peer reviewed journal for SOF medical professionals (J Spec Oper Med) Vol. 14 Issue 2 Pg. 35-37 ( 2014) ISSN: 1553-9768 [Print] United States
• PMID: 24952038 (Publication Type: Comparative Study, Journal Article)
• Copyright: 2014.

Chemical References

• Neuromuscular Depolarizing Agents
• Succinylcholine

Topics

• Administration, Intravenous
• Animals
• Cross-Over Studies
• Electromyography
• Infusions, Intraosseous
• Muscle, Skeletal (drug effects)
• Neuromuscular Blockade (methods)
• Neuromuscular Depolarizing Agents (administration & dosage, pharmacology)
• Paralysis
• Succinylcholine (administration & dosage, pharmacology)
• Sus scrofa
• Swine