Abstract | OBJECTIVE: SUBJECTS AND METHODS: We examined 32 patients (27 men and five women; mean age ± SD, 70.0 ± 6.8 years; seven GOLD stage 0 [at risk for COPD], 19 GOLD stage 1-2 [mild to moderate airflow limitation], and six GOLD stage 3-4 [severe to very severe airflow limitation]) using inspiratory CT. Mean LA and %WA were measured for the first (main bronchi), third, and fifth generations of five bronchi in each lobe and the ratios of peripheral to central airways were calculated (third to first, fifth to first, and fifth to third) and statistically compared. RESULTS: The fifth-generation LA, LA fifth to first, and LA fifth to third significantly decreased and fifth %WA, %WA fifth to first, and %WA fifth to third also increased with progression of GOLD stage (p < 0.05), but central measurements, including first and third generations, did not. There were significant differences between GOLD 0 and GOLD 1-2 for %WA fifth to third and LA fifth to third and between GOLD 0 and GOLD 3-4 for all six parameters (p < 0.05); %WA fifth to third had the best cutoff value of 1.02 (sensitivity, 92%; specificity, 86%) for diagnosis of COPD (GOLD 1-4). The %WA fifth to first of 1.51 (sensitivity, 83%; specificity, 89%) was best for diagnosis of GOLD 3-4. CONCLUSION: Ratios of peripheral-to-central airway LA and %WA show improved correlation with COPD severity.
|
Authors | Tomoaki Sasaki, Koji Takahashi, Nobuhisa Takada, Yoshinobu Ohsaki |
Journal | AJR. American journal of roentgenology
(AJR Am J Roentgenol)
Vol. 203
Issue 1
Pg. 78-84
(Jul 2014)
ISSN: 1546-3141 [Electronic] United States |
PMID | 24951198
(Publication Type: Journal Article)
|
Topics |
- Aged
- Bronchi
(physiopathology)
- Bronchography
- Female
- Humans
- Male
- Predictive Value of Tests
- Prospective Studies
- Pulmonary Disease, Chronic Obstructive
(diagnostic imaging, physiopathology)
- Radiographic Image Interpretation, Computer-Assisted
- Respiratory Function Tests
- Severity of Illness Index
- Tomography, X-Ray Computed
|