Abstract |
The aim of this study was to evaluate the efficacy of helical tomotherapy plus capecitabine as a preoperative chemoradiotherapy (CRT) in patients with locally advanced rectal cancer (LARC). Thirty-six LARC patients receiving preoperative CRT were analyzed. Radiotherapy (RT) consisted of 45 Gy to the regional lymph nodes and simultaneous-integrated boost (SIB) 50.4 Gy to the tumor, 5 days/week for 5 weeks. Chemotherapy consisted of capecitabine 850 mg/m(2), twice daily, during the RT days. Patients underwent surgery 6-8 weeks after completion of CRT. Information was collected for patient characteristics, treatment response, and acute and late toxicities. Grade 3/4 (G3+) toxicities occurred in 11.1% of patients (4/36). Sphincter preservation rate was 85.2% (23/27). Five patients (14.3%) achieved pathological complete response. Tumor, nodal, and ypT0-2N0 downstaging were noted in 60% (21/35), 69.6% (16/23), and 57.1% (20/35). Tumor regression grade 2~4 was achieved in 28 patients (80%). After a median follow-up time of 35 months, the most common G3+ late morbidity was ileus and fistula (5.7%, 2/35). The study showed that capecitabine plus helical tomotherapy with an SIB is feasible in treatment of LARC. The treatment modality can achieve a very encouraging sphincter preservation rate and a favorable ypT0-2N0 downstaging rate without excessive toxicity.
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Authors | Ming-Yii Huang, Chin-Fan Chen, Chun-Ming Huang, Hsiang-Lin Tsai, Yung-Sung Yeh, Cheng-Jen Ma, Chan-Han Wu, Chien-Yu Lu, Chee-Yin Chai, Chih-Jen Huang, Jaw-Yuan Wang |
Journal | BioMed research international
(Biomed Res Int)
Vol. 2014
Pg. 352083
( 2014)
ISSN: 2314-6141 [Electronic] United States |
PMID | 24949438
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Deoxycytidine
- Capecitabine
- Fluorouracil
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Capecitabine
- Combined Modality Therapy
- Deoxycytidine
(administration & dosage, analogs & derivatives)
- Female
- Fluorouracil
(administration & dosage, analogs & derivatives)
- Humans
- Male
- Middle Aged
- Neoplasm Recurrence, Local
(drug therapy, mortality, pathology, surgery)
- Neoplasm Staging
- Preoperative Care
- Radiotherapy, Intensity-Modulated
- Rectal Neoplasms
(drug therapy, mortality, pathology, surgery)
- Treatment Outcome
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