Abstract | BACKGROUND: METHODS: The animals were forced to swim individually for a period of 6min every day for 15 days to induce chronic stress. The locomotor activity, anxiety-like behavior, and memory retention were evaluated in chronically stressed animals, followed by biochemical estimations and neuroinflammatory surge in the brain. RESULTS: Chronic treatment with trimethylgallic acid esters for 15 days significantly reversed the chronic stress-induced behavioral (impaired locomotor activity, anxiety-like behavior, and decreased percentage of memory retention), biochemical (increased lipid peroxidation and nitrite levels; decreased glutathione levels, superoxide dismutase and catalase activities), and inflammation surge (serum TNF-α) in stressed mice. CONCLUSIONS: The study revealed that trimethylgallic acid esters could ameliorate chronic stress-induced various behavioral and biochemical alterations in mice, showing protective effects against chronic stress.
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Authors | Mamta Sachdeva Dhingra, Sameer Dhingra, Rachna Kumria, Renu Chadha, Tejvir Singh, Anil Kumar, Maninder Karan |
Journal | Pharmacological reports : PR
(Pharmacol Rep)
Vol. 66
Issue 4
Pg. 606-12
(Aug 2014)
ISSN: 2299-5684 [Electronic] Switzerland |
PMID | 24948061
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved. |
Chemical References |
- Antioxidants
- Esters
- Gallic Acid
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Topics |
- Animals
- Antioxidants
(administration & dosage, chemistry, therapeutic use)
- Anxiety
(drug therapy, enzymology, metabolism, psychology)
- Behavior, Animal
(drug effects)
- Chronic Disease
- Disease Models, Animal
- Esters
- Gallic Acid
(analogs & derivatives, chemistry, therapeutic use)
- Lipid Peroxidation
(drug effects)
- Male
- Maze Learning
(drug effects)
- Mice
- Motor Activity
(drug effects)
- Oxidative Stress
(drug effects)
- Stress, Psychological
(drug therapy, enzymology, metabolism, psychology)
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