Abstract | OBJECTIVE: METHODS: RESULTS: The concentration of citrullinated ENA-78/CXCL5 was significantly higher in RA sera and SF than in normal sera and in SF from patients with other rheumatic diseases including OA. In RA SF, a strong correlation between the amount of citrullinated ENA-78/CXCL5 and the C-reactive protein level or the erythrocyte sedimentation rate was observed. Citrullinated ENA-78/CXCL5 induced monocyte chemotaxis via CXCR1 and CXCR2, while noncitrullinated ENA-78/CXCL5 did not. In a mouse model of inflammatory arthritis, citrullinated ENA-78/CXCL5 induced more severe inflammation and recruited more monocytes than did noncitrullinated ENA-78/CXCL5. CONCLUSION: Citrullinated ENA-78/CXCL5 is highly correlated with RA disease activity and, unlike noncitrullinated ENA-78/CXCL5, recruits monocytes. These results indicate that citrullinated ENA-78/CXCL5 may exert previously unrecognized inflammatory properties in RA by recruiting monocytes to inflamed joint tissue.
|
Authors | Ken Yoshida, Olexandr Korchynskyi, Paul P Tak, Takeo Isozaki, Jeffrey H Ruth, Phillip L Campbell, Dominique L Baeten, Danielle M Gerlag, M Asif Amin, Alisa E Koch |
Journal | Arthritis & rheumatology (Hoboken, N.J.)
(Arthritis Rheumatol)
Vol. 66
Issue 10
Pg. 2716-27
(Oct 2014)
ISSN: 2326-5205 [Electronic] United States |
PMID | 24943990
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
|
Copyright | Copyright © 2014 by the American College of Rheumatology. |
Chemical References |
- Chemokine CCL2
- Chemokine CCL3
- Chemokine CXCL5
|
Topics |
- Animals
- Arthritis, Rheumatoid
(metabolism)
- Chemokine CCL2
(metabolism)
- Chemokine CCL3
(metabolism)
- Chemokine CXCL5
(metabolism)
- Female
- Humans
- Knee Joint
(metabolism)
- Male
- Mice
- Middle Aged
- Monocytes
(metabolism)
- Osteoarthritis
(metabolism)
- Synovial Fluid
(metabolism)
|