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[Prevalence and significance of immunoglobulin G-anti-cyclic citrullinated peptide antibodies in primary Sjogren's syndrome patients].

AbstractOBJECTIVE:
To investigate the prevalence and significance of IgG-anti-cyclic citrullinated peptides (CCP) antibody in PSS patients.
METHODS:
A total of 120 patients diagnosed with PSS were investigated in the first affiliated hospital of Baotou Medical College from March 2006 to December 2009. IgG-anti-CCP antibody was assayed by enzyme-linked immunosorbent assay (ELISA), also anti-Sjogren's syndrome type A (SSA) and Sjogren's syndrome type B (SSB) antibody were assayed by immunoblotting. Erythrocyte sedimentation rate (ESR) was assayed by westergren in serum, and C reactive protein (CRP), IgA, IgM, IgG and IgM-RF were detected by immune turbidimetric. At the same time, clinical symptoms and involvement of important organs were observed. Following up the patients above 3 years, the primary Sjogren's syndrome (PSS) patients who had progressed to rheumatoid arthritis (RA) were evaluated.
RESULTS:
The positive rate of anti-CCP antibody in the PSS patients was 19.17%; After 3 years, more patients who were positive for anti-CCP antibody had progressed to RA (χ² = 5.015,P=0.022) than the patients in negative group; The patients in anti-CCP antibody positive group were more prone to joint involvement (χ² = 8.058,P<0.05), more swollen joints (U=152.00, P<0.05) and longer morning stiffness (U=100.00, P<0.05) than the patients with negative anti-CCP antibody, but the involvement of vital organs in the two groups had no significant difference (χ² = 0.208,0.099,0.000 and 0.122, P>0.05); The positive rate of anti-SSA and SSB antibody in anti-CCP antibody positive group and negative group had no significant difference (χ² = 0.008 and 0.56, P>0.05); Multiple linear regression showed that the level of anti-CCP antibody was positively correlated with IgM-RF levels in the PSS patients (B=0.61, 95% CI=0.36-0.86, P<0.05), but had no significant correlation with ESR, CRP, IgA, IgM and IgG levels (P>0.05).There were no significant differences in the level of ESR, CRP, IgA, IgM and IgG between anti-CCP antibody positive group and negative group (P>0.05), but the level of IgM-RF in anti-CCP antibody positive group was significantly higher than that in the negative group (U=623.50, P<0.05).
CONCLUSION:
Positive rate of IgG-anti-CCP antibody in PSS is 19.17%, also it is associated with joint involvement and more prone to progressing to RA.
AuthorsYuan Liu, Yong-fu Wang, Kai-li Wang, Feng-feng Lv
JournalBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences (Beijing Da Xue Xue Bao Yi Xue Ban) Vol. 46 Issue 3 Pg. 478-82 (Jun 18 2014) ISSN: 1671-167X [Print] China
PMID24943033 (Publication Type: Journal Article)
Chemical References
  • Autoantibodies
  • Biomarkers
  • Peptides, Cyclic
  • cyclic citrullinated peptide
  • C-Reactive Protein
Topics
  • Arthritis, Rheumatoid (pathology)
  • Autoantibodies (blood)
  • Biomarkers (blood)
  • C-Reactive Protein (metabolism)
  • Enzyme-Linked Immunosorbent Assay
  • Humans
  • Peptides, Cyclic (immunology)
  • Prevalence
  • Sjogren's Syndrome (immunology, pathology)

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