Massive splenic infarction and portal vein thrombosis in children with chronic myeloid leukemia.

Abstract

Massive splenic infarction and portal vein thrombosis (PVT) due to chronic myeloid leukemia (CML) is extremely rare. We describe 2 children who were presented with massive splenic infarction and PVT in the course of CML. Massive splenic infarction and PVT treated with splenectomy in one and with medical treatment in another in whom PVT resolved by cytoreductive treatment, led to downsizing of spleen or splenectomy. Splenic infarct and PVT should be considered in CML patients with long-lasting severe abdominal pain despite appropriate medical attempts. Splenectomy should be spared for persistent symptoms and complications.

• Authors: Tekin Aksu, Arzu Y Erdem, Ali Fettah, Dilek Kaçar, Zekai Avci, Nese Yarali, Bahattin Tunc
• Journal: Journal of pediatric hematology/oncology (J Pediatr Hematol Oncol) Vol. 36 Issue 7 Pg. e471-2 (Oct 2014) ISSN: 1536-3678 [Electronic] United States
• PMID: 24942025 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antineoplastic Agents

Topics

• Antineoplastic Agents (therapeutic use)
• Child
• Female
• Humans
• Leukemia, Myelogenous, Chronic, BCR-ABL Positive (complications, drug therapy)
• Male
• Portal Vein
• Remission Induction
• Severity of Illness Index
• Splenectomy
• Splenic Infarction (etiology, surgery)
• Thrombosis (etiology, surgery)