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Cardiovascular reflexes during treatment of social phobia with moclobemide.

AbstractINTRODUCTION:
Cardiovascular side-effects are less frequent with moclobemide than with tricyclic or monoamine oxidase inhibitor antidepressants. We performed a detailed assessment of cardiovascular reflexes in 15 patients meeting DSM-III-R criteria for social phobia, before treatment and whilst taking a stable dose of moclobemide for a median of 7 weeks.
METHOD:
Cardiovascular reflex responses to standing, deep breathing and the Valsalva manoeuvre were assessed using beat-by-beat blood pressure and heart rate recording.
RESULTS:
Moclobemide produced a statistically significant, but clinically modest, degree of improvement in social phobia symptoms. Only the maximum change in heart rate from supine to standing showed a change from before to after treatment, which was not statistically significant after Bonferroni correction, and there was no consistent pattern of altered sympathetic or parasympathetic function.
CONCLUSION:
Moclobemide is relatively devoid of cardiovascular autonomic effects in physically healthy subjects with social phobia. ( Int J Psych Clin Pract 2001; 5:27-31).
AuthorsN J Coupland Caroline Bell John P Potokar Jayne E Bailey David J Nutt
JournalInternational journal of psychiatry in clinical practice (Int J Psychiatry Clin Pract) Vol. 5 Issue 1 Pg. 27-31 ( 2001) ISSN: 1365-1501 [Print] England
PMID24936993 (Publication Type: Journal Article)

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