Previous studies have suggested that the
8-oxoguanine DNA glycosylase gene (OGG1) has potentially influenced the risk of
pancreatic cancer. The objective of this study was to assess the association between single nucleotide polymorphisms (SNPs) of OGG1 gene and risk of
pancreatic cancer. A case-control study has been conducted in 370
pancreatic cancer patients and 395 healthy controls. Genotypes were determined using the polymerase chain reaction-restriction fragment length polymorphism and
DNA sequencing methods. The association analysis was evaluated by the unconditional logistic regression test. Our data suggested that the distributions of alleles and genotypes were statistically different between
pancreatic cancer patients and healthy controls. The c.307G>C SNP was associated with the decreased risk of
pancreatic cancer (C vs. G: OR 0.73, 95 % CI 0.59-0.91, P = 0.006). As for c.828A>G SNP, the significantly decreased risk of
pancreatic cancer was detected (G vs. A: OR 0.74, 95 % CI 0.59-0.92, P = 0.006). The allele C of c.307G>C and allele G of c.828A>G SNPs might be associated with a protection from
pancreatic cancer. Findings from this study indicate that OGG1 SNPs are associated with
pancreatic cancer risk in Chinese Han population and could be useful molecular
biomarkers for assessing the risk of
pancreatic cancer.