Abstract | BACKGROUND: MATERIALS AND METHODS: A total of 28 cases (18 specimens of PA [control] and 10 blocks of MEC [case]) were selected for analysis by streptavidin- biotin peroxidase method with antibody against Bcl-2. The percentage of positive cells was calculated from a minimum of 1000 neoplastic cells and H-score was identified (% positive cells × intensity of staining). Data were analyzed using two-way ANOVA, t-test, Spearman, Chi-square and Fisher tests (α = 0.05). RESULTS: bcl-2 expression was shown in 13 cases (71%) of PA and 3 cases (30%) of MEC. In addition, four cases of PA showed strong staining. There was a significant difference between the expression intensity of Bcl-2 in the two tumors (P = 0.048) according to ANOVA. No correlation was observed between Bcl-2 expression with the size and location of tumors (P > 0.05). CONCLUSION: Bcl-2 expression might be used for differentiating these tumors. Bcl-2 protein was overexpressed in PA compared with MEC. Hence, it seems that unlike what was observed in PA, Bcl-2 probably does not participate in the pathogenesis of MEC.
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Authors | Saede Atarbashi, Maryam Elahi, Mehdi Khani, Vahid Rakhshan |
Journal | Dental research journal
(Dent Res J (Isfahan))
Vol. 11
Issue 2
Pg. 257-63
(Mar 2014)
ISSN: 1735-3327 [Print] Iran |
PMID | 24932199
(Publication Type: Journal Article)
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