HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Evaluation of new Deflux administration techniques: intraureteric HIT and Double HIT for the endoscopic correction of vesicoureteral reflux.

Abstract
Vesicoureteral reflux (VUR) is one of the most common urologic diagnoses affecting children, and optimal treatment requires an individualized approach that considers potential risks. Management options include observation with or without continuous antibiotic prophylaxis and surgical correction via endoscopic, open or laparoscopic/robotic approaches. Endoscopic correction of VUR is an outpatient procedure associated with decreased morbidity compared with ureteral reimplantation. The concept of ureteral hydrodistention and intraluminal submucosal injection (Hydrodistention Implantation Technique [HIT]) has led to improved success rates in eliminating VUR compared with the subureteral transurethral injection technique. Further modifications now include use of proximal and distal intraluminal injections (Double HIT) that result in coaptation of both the ureteral tunnel and orifice. Endoscopic injection of dextranomer/hyaluronic acid copolymer, via the HIT and Double HIT, has emerged as a highly successful, minimally invasive alternative to open surgical correction, with minimal associated morbidity.
AuthorsAndrew J Kirsch, Angela M Arlen
JournalExpert review of medical devices (Expert Rev Med Devices) Vol. 11 Issue 5 Pg. 439-46 (Sep 2014) ISSN: 1745-2422 [Electronic] England
PMID24931132 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Dextrans
  • deflux
  • Hyaluronic Acid
Topics
  • Absorbable Implants
  • Dextrans (pharmacology)
  • Humans
  • Hyaluronic Acid (pharmacology)
  • Ureteroscopy (instrumentation, methods)
  • Vesico-Ureteral Reflux (surgery)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: