Abstract | BACKGROUND: In recent years, some reports have suggested that papillary thyroid cancers are more frequently associated with lymphocytic thyroiditis or Hashimoto's thyroiditis. This study investigated a potential increase in the prevalence of chronic lymphocytic thyroiditis among papillary thyroid cancer patients. MATERIALS AND METHODS: We used national epidemiological survey data on thyroid cancer patients diagnosed in 1999, 2005, and 2008. A retrospective medical record survey was conducted by representative sampling of a national cancer incidence database. The analysis included 5,378 papillary thyroid cancer patients aged 20-79 years. We calculated the age-standardized prevalence and age-adjusted prevalence ratios using a binomial regression model with a log link for the prevalence of chronic lymphocytic thyroiditis among papillary thyroid cancer patients by sex for each year. RESULTS: The prevalence of chronic lymphocytic thyroiditis among papillary thyroid cancer patients was 4.0% and 12.8% for men and women in 1999, 6.5% and 24.6% in 2005, and 10.7% and 27.6% in 2008, respectively. Between 1999 and 2008, the age-standardized prevalence of chronic lymphocytic thyroiditis increased 4.1-fold in male patients and 2.0-fold in female patients with papillary thyroid cancer. The prevalence of other thyroid diseases, however, did not increase in either gender. CONCLUSIONS: Among Korean papillary thyroid cancer patients, the prevalence of chronic lymphocytic thyroiditis increased between 1999 and 2008, whereas the prevalence of other thyroid disorders did not change.
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Authors | Chang-Mo Oh, Sohee Park, Joo Young Lee, Young-Joo Won, Aesun Shin, Hyun-Joo Kong, Kui-Sun Choi, You Jin Lee, Ki-Wook Chung, Kyu-Won Jung |
Journal | PloS one
(PLoS One)
Vol. 9
Issue 6
Pg. e99054
( 2014)
ISSN: 1932-6203 [Electronic] United States |
PMID | 24927027
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Adult
- Aged
- Carcinoma
(complications, pathology)
- Carcinoma, Papillary
- Female
- Hashimoto Disease
(complications, epidemiology)
- Humans
- Male
- Middle Aged
- Prevalence
- Regression Analysis
- Republic of Korea
(epidemiology)
- Retrospective Studies
- Sex Factors
- Thyroid Cancer, Papillary
- Thyroid Neoplasms
(complications, pathology)
- Young Adult
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