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Increased prevalence of chronic lymphocytic thyroiditis in Korean patients with papillary thyroid cancer.

AbstractBACKGROUND:
In recent years, some reports have suggested that papillary thyroid cancers are more frequently associated with lymphocytic thyroiditis or Hashimoto's thyroiditis. This study investigated a potential increase in the prevalence of chronic lymphocytic thyroiditis among papillary thyroid cancer patients.
MATERIALS AND METHODS:
We used national epidemiological survey data on thyroid cancer patients diagnosed in 1999, 2005, and 2008. A retrospective medical record survey was conducted by representative sampling of a national cancer incidence database. The analysis included 5,378 papillary thyroid cancer patients aged 20-79 years. We calculated the age-standardized prevalence and age-adjusted prevalence ratios using a binomial regression model with a log link for the prevalence of chronic lymphocytic thyroiditis among papillary thyroid cancer patients by sex for each year.
RESULTS:
The prevalence of chronic lymphocytic thyroiditis among papillary thyroid cancer patients was 4.0% and 12.8% for men and women in 1999, 6.5% and 24.6% in 2005, and 10.7% and 27.6% in 2008, respectively. Between 1999 and 2008, the age-standardized prevalence of chronic lymphocytic thyroiditis increased 4.1-fold in male patients and 2.0-fold in female patients with papillary thyroid cancer. The prevalence of other thyroid diseases, however, did not increase in either gender.
CONCLUSIONS:
Among Korean papillary thyroid cancer patients, the prevalence of chronic lymphocytic thyroiditis increased between 1999 and 2008, whereas the prevalence of other thyroid disorders did not change.
AuthorsChang-Mo Oh, Sohee Park, Joo Young Lee, Young-Joo Won, Aesun Shin, Hyun-Joo Kong, Kui-Sun Choi, You Jin Lee, Ki-Wook Chung, Kyu-Won Jung
JournalPloS one (PLoS One) Vol. 9 Issue 6 Pg. e99054 ( 2014) ISSN: 1932-6203 [Electronic] United States
PMID24927027 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Topics
  • Adult
  • Aged
  • Carcinoma (complications, pathology)
  • Carcinoma, Papillary
  • Female
  • Hashimoto Disease (complications, epidemiology)
  • Humans
  • Male
  • Middle Aged
  • Prevalence
  • Regression Analysis
  • Republic of Korea (epidemiology)
  • Retrospective Studies
  • Sex Factors
  • Thyroid Cancer, Papillary
  • Thyroid Neoplasms (complications, pathology)
  • Young Adult

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