Sirolimus-related systemic thrombotic microangiopathy after renal transplantation.

Abstract

We describe the case of a renal transplant patient who developed de novo biopsy-proven thrombotic microangiopathy (TMA) and deep venous thrombosis after treatment with sirolimus (SRL). We discuss the clinical course, diagnosis and therapeutics of this patient in the context of the literature.

• Authors: Simone Negrini, Antoine Durrbach, Laurent Becquemont
• Journal: Therapie (Therapie) 2014 Mar-Apr Vol. 69 Issue 2 Pg. 175-7 ISSN: 0040-5957 [Print] France
• PMID: 24926637 (Publication Type: Case Reports, Letter)
• Copyright: © 2014 Société Française de Pharmacologie et de Thérapeutique.

Chemical References

• Immunosuppressive Agents
• Sirolimus

Topics

• Aged
• Humans
• Immunosuppressive Agents (administration & dosage, adverse effects)
• Kidney (blood supply, pathology)
• Kidney Transplantation (adverse effects)
• Male
• Sirolimus (administration & dosage, adverse effects)
• Thrombotic Microangiopathies (chemically induced, diagnosis)
• Transplantation Conditioning (adverse effects)
• Venous Thrombosis (chemically induced, diagnosis)