ParaPep: a web resource for experimentally validated antiparasitic peptide sequences and their structures.

Abstract

ParaPep is a repository of antiparasitic peptides, which provides comprehensive information related to experimentally validated antiparasitic peptide sequences and their structures. The data were collected and compiled from published research papers, patents and from various databases. The current release of ParaPep holds 863 entries among which 519 are unique peptides. In addition to peptides having natural amino acids, ParaPep also consists of peptides having d-amino acids and chemically modified residues. In ParaPep, most of the peptides have been evaluated for growth inhibition of various species of Plasmodium, Leishmania and Trypanosoma. We have provided comprehensive information about these peptides that include peptide sequence, chemical modifications, stereochemistry, antiparasitic activity, origin, nature of peptide, assay types, type of parasite, mode of action and hemolytic activity. Structures of peptides consisting of natural, as well as modified amino acids have been determined using state-of-the-art software, PEPstr. To facilitate users, various user-friendly web tools, for data fetching, analysis and browsing, have been integrated. We hope that ParaPep will be advantageous in designing therapeutic peptides against parasitic diseases. Database URL: http://crdd.osdd.net/raghava/parapep/

• Authors: Divya Mehta, Priya Anand, Vineet Kumar, Anshika Joshi, Deepika Mathur, Sandeep Singh, Abhishek Tuknait, Kumardeep Chaudhary, Shailendra K Gautam, Ankur Gautam, Grish C Varshney, Gajendra P S Raghava
• Journal: Database : the journal of biological databases and curation (Database (Oxford)) Vol. 2014 ( 2014) ISSN: 1758-0463 [Electronic] England
• PMID: 24923818 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © The Author(s) 2014. Published by Oxford University Press.

Chemical References

• Antiparasitic Agents
• Peptides

Topics

• Amino Acid Sequence
• Animals
• Antiparasitic Agents (chemistry, pharmacology)
• Databases, Protein
• Internet
• Molecular Sequence Data
• Parasites (drug effects)
• Peptides (chemistry, pharmacology)
• Reproducibility of Results
• User-Computer Interface