Non-ergot dopamine agonist rotigotine as a promising therapeutic tool in atypical parkinsonism syndromes: a 24 months pilot observational open-label study.

Abstract

Rotigotine (RTG) is a non-ergot dopamine agonist developed as a new transdermal formulation, indicated for use in early and advanced Parkinson's disease (PD). The potential advantages of the RTG patch include immediacy of effect onset, constant drug delivery, better tolerability avoiding drug peaks and easy of use, helping patient's compliance. So, RTG patch appears to be a suitable candidate in the treatment of patients with atypical parkinsonism. The present is an observational study to evaluate the efficacy and tolerability of RTG in patients affected by atypical parkinsonian disorders. 61 subjects with diagnosis of atypical parkinsonian disorders were treated with transdermal RTG. Diagnosis was: Parkinson disease with dementia, multiple system atrophy parkinsonian type, multiple system atrophy cerebellar type, progressive sopranuclear palsy, cortico-basal degeneration, Lewy body dementia and fronto-temporal dementia with parkinsonism. Patients were evaluated by UPDRS-III, NPI, MMSE and adverse events (AEs) were recorded. Patients treated with RTG show an overall decrease of UPDRS III scores without increasing behavioral disturbances. Main adverse events (AE) were hypotension (14 patients), nausea (13), vomiting (5), drowsiness (5), tachycardia (2) dystonia (3 patients, all treated with concomitant l-dopa). On the whole, 16 patients were affected by AE and 7 patients suspended RTG treatment due to AE (vomiting, tachycardia and sleepiness). In our population transdermal RTG seems to be effective and well tolerated. Due to its system of drug delivery, RTG appears to be a suitable therapy in elderly patients as it has a good tolerability profile, improves patient's compliance and helps management of fragile patients.

• Authors: D V Moretti, G Binetti, O Zanetti, G B Frisoni
• Journal: Neuropharmacology (Neuropharmacology) Vol. 85 Pg. 284-9 (Oct 2014) ISSN: 1873-7064 [Electronic] England
• PMID: 24915072 (Publication Type: Clinical Trial, Journal Article, Observational Study)
• Copyright: Copyright © 2014 Elsevier Ltd. All rights reserved.

Chemical References

• Antiparkinson Agents
• Dopamine Agonists
• Tetrahydronaphthalenes
• Thiophenes
• rotigotine

Topics

• Administration, Cutaneous
• Aged
• Antiparkinson Agents (administration & dosage, adverse effects)
• Dopamine Agonists (administration & dosage, adverse effects)
• Follow-Up Studies
• Humans
• Parkinsonian Disorders (drug therapy)
• Psychiatric Status Rating Scales
• Severity of Illness Index
• Tetrahydronaphthalenes (administration & dosage, adverse effects)
• Thiophenes (administration & dosage, adverse effects)
• Transdermal Patch (adverse effects)
• Treatment Outcome