Abstract | AIM: MATERIALS & METHODS: RESULTS: The administration of the transferrin-conjugated generation 3 diaminobutyric polypropylenimine dendriplex encoding TNF-a resulted in tumor suppression for 60% of PC-3 and 50% of DU145 prostate tumors. CONCLUSION:
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Authors | Majed Al Robaian, Ker Yi Chiam, David R Blatchford, Christine Dufès |
Journal | Nanomedicine (London, England)
(Nanomedicine (Lond))
Vol. 9
Issue 4
Pg. 421-34
(Apr 2014)
ISSN: 1748-6963 [Electronic] England |
PMID | 24910874
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Dendrimers
- Polypropylenes
- TNF-Related Apoptosis-Inducing Ligand
- Transferrin
- Tumor Necrosis Factor-alpha
- poly(propyleneimine)
- Interleukin-12
- DNA
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Topics |
- Administration, Intravenous
- Animals
- Cell Line, Tumor
- DNA
(administration & dosage, genetics, therapeutic use)
- Dendrimers
(chemistry)
- Gene Transfer Techniques
- Genetic Therapy
(methods)
- Humans
- Interleukin-12
(genetics)
- Male
- Mice
- Mice, Inbred BALB C
- Plasmids
(administration & dosage, genetics, therapeutic use)
- Polypropylenes
(chemistry)
- Prostate
(drug effects, metabolism, pathology)
- Prostatic Neoplasms
(genetics, pathology, therapy)
- TNF-Related Apoptosis-Inducing Ligand
(genetics)
- Transferrin
(chemistry)
- Tumor Necrosis Factor-alpha
(genetics)
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