HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Escheriosome-mediated cytosolic delivery of PLK1-specific siRNA: potential in treatment of liver cancer in BALB/c mice.

AbstractAIM:
In the present study, the anticancer efficacy of a novel escheriosome-based formulation of PLK1-specific siRNA was evaluated against liver cancer in BALB/c mice.
MATERIALS & METHODS:
The escheriosome-based siRNA nanoparticles were prepared using lipids isolated from Escherichia coli. The escheriosomes were characterized for size, surface charge and stability. The anticancer potential of PLK1-specific siRNA formulation was ascertained on the basis of expression of pro-/anti-apoptotic factors and histopathological studies.
RESULTS:
The escheriosome-entrapped siRNA was found to be released in surrounding milieu in a sustained manner. The nanoformulation was successful in modulating proapoptotic factors and eventually helped in better survival of the treated animals.
CONCLUSION:
Our data demonstrate the efficacy of systemically administered siRNA in the treatment of experimental liver cancer. This novel therapeutic strategy may be applicable to a broad range of cancers in patients with the obstinate form of the disease.
AuthorsArun Chauhan, Swaleha Zubair, Ahmad Nadeem, Sajid Ali Ansari, Mohammad Yunus Ansari, Owais Mohammad
JournalNanomedicine (London, England) (Nanomedicine (Lond)) Vol. 9 Issue 4 Pg. 407-20 (Apr 2014) ISSN: 1748-6963 [Electronic] England
PMID24910873 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Cell Cycle Proteins
  • Lipids
  • Proto-Oncogene Proteins
  • RNA, Small Interfering
  • Protein Serine-Threonine Kinases
  • polo-like kinase 1
Topics
  • Animals
  • Cell Cycle Proteins (genetics)
  • Drug Delivery Systems
  • Escherichia coli (chemistry)
  • Female
  • Genetic Therapy
  • Lipids (chemistry, isolation & purification)
  • Liver (pathology)
  • Liver Neoplasms (genetics, pathology, therapy)
  • Mice
  • Mice, Inbred BALB C
  • Nanoparticles (chemistry)
  • Protein Serine-Threonine Kinases (genetics)
  • Proto-Oncogene Proteins (genetics)
  • RNA Interference
  • RNA, Small Interfering (administration & dosage, genetics, therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: