Abstract |
Brain abscess is a focal suppurative process. Host inflammatory response in Gram type and specific bacteria has not been studied in brain abscess. A total of 57 brain abscess patients with monomicrobial infections were studied for Th1 (TNF-α, IFN-γ, IL1-β), Th2 (IL-4, IL-10) and Th17 (IL-17, IL-23) cytokine response by reverse-transcriptase PCR and ELISA. Th1 and Th17 cytokines were significantly elevated in Gram positive (Staphylococcus aureus and Streptococcus intermedius) and Th2 cytokine (IL-10) in Gram negative (Bacteroides fragilis and Escherichia coli) infections (p<0.05). Cytokine levels were significantly higher in abscess than blood (p<0.001). Elevated levels of several inflammatory cytokines (TNF-α, IFN-γ, IL1-β, IL-17 and IL-23) were associated with the duration of symptoms; predisposing factors also influenced the levels of several cytokines. The expression of inflammatory cytokines in abscess was influenced by the bacterial pathogen, duration of symptoms and predisposing factors. Local milieu of brain plays significant role in secretion of various cytokines.
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Authors | Anamika Bajpai, Kashi Nath Prasad, Priyanka Mishra, Aloukick Kumar Singh, Rakesh Kumar Gupta, Bal Krishan Ojha |
Journal | Journal of neuroimmunology
(J Neuroimmunol)
Vol. 273
Issue 1-2
Pg. 96-102
(Aug 15 2014)
ISSN: 1872-8421 [Electronic] Netherlands |
PMID | 24910026
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 Elsevier B.V. All rights reserved. |
Chemical References |
- Antibodies
- Cytokines
- RNA, Messenger
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Topics |
- Adult
- Age Factors
- Analysis of Variance
- Antibodies
(blood)
- Bacterial Infections
(classification, complications)
- Brain
(microbiology, pathology)
- Brain Abscess
(etiology, microbiology)
- Cells, Cultured
- Cytokines
(genetics, immunology, metabolism)
- Enzyme-Linked Immunosorbent Assay
- Female
- Gene Expression Regulation
(physiology)
- Humans
- Magnetic Resonance Imaging
- Male
- RNA, Messenger
- Young Adult
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