[Oxidative stress and antioxidant therapy with alpha-lipoic acid inclusion in acute poisoning by herbicide based on 2,4-dichlorphenoxyacetic acid].

Abstract

In patients with acute poisoning amine salt herbicide 2,4-D develops oxidative stress with simultaneous inhibition of intracellular and extracellular antioxidant factors. These changes are more pronounced with neurological disorders that occur in conjunction with a toxic damage of liver or heart. The inclusion of a comprehensive detoxification therapy alpha-lipoic acid not only promotes a more pronounced therapeutic effect but also an earlier recourse cytolytic syndrome, a marked recovery of levels of malondialdehyde and indices of antioxidant system (superoxide dismutase and ceruloplasmin) than for patients in the comparison group.

• Authors: O A Kharchenko, H M Balan, N N Bubalo, T V Mymrenko
• Journal: Likars'ka sprava (Lik Sprava) 2014 Jan-Feb Issue 1-2 Pg. 140-5 ISSN: 1019-5297 [Print] Ukraine
• PMID: 24908976 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antioxidants
• Herbicides
• 2,4-Dichlorophenoxyacetic Acid
• Thioctic Acid

Topics

• 2,4-Dichlorophenoxyacetic Acid (poisoning)
• Acute Disease
• Adult
• Agricultural Workers' Diseases (chemically induced, drug therapy, metabolism)
• Antioxidants (administration & dosage, therapeutic use)
• Drug Therapy, Combination
• Female
• Heart Function Tests
• Herbicides (poisoning)
• Humans
• Liver Function Tests
• Middle Aged
• Occupational Exposure (adverse effects)
• Occupational Health
• Oxidative Stress (drug effects)
• Thioctic Acid (administration & dosage, therapeutic use)
• Treatment Outcome
• Young Adult