Intratypic heterologous vaccination of calves can induce an antibody response in presence of maternal antibodies against foot-and-mouth disease virus.

Abstract

BACKGROUND:

Maternal antibodies can interfere with foot-and-mouth disease vaccination. In this study we determined whether intratypic heterologous vaccination could help to improve herd immunity.

RESULTS:

In unvaccinated calves, a half-life of maternal antibodies of 21 days was determined. At two weeks of age, calves without maternal antibodies showed a good antibody response against both vaccines used in the trial, while in calves with maternal antibodies no antibody response to homologous vaccination (A Turkey 14/98) but a limited antibody response to intratypic heterologous vaccination (A22 Iraq) was observed.

CONCLUSION:

Two weeks old calves without maternal antibodies respond well to vaccination, but when emergency vaccination is carried out in a region that uses prophylactic vaccination, using an intratypic heterologous vaccine strain may improve the immunity in calves with maternal antibodies.

• Authors: Aldo Dekker, Phaedra Eblé, Norbert Stockhofe, Gilles Chénard
• Journal: BMC veterinary research (BMC Vet Res) Vol. 10 Pg. 127 (Jun 06 2014) ISSN: 1746-6148 [Electronic] England
• PMID: 24906852 (Publication Type: Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Viral
• Viral Vaccines

Topics

• Animals
• Antibodies, Viral (blood)
• Cattle
• Cattle Diseases (blood, prevention & control)
• Foot-and-Mouth Disease (blood, prevention & control)
• Foot-and-Mouth Disease Virus (immunology)
• Immunity, Maternally-Acquired
• Immunization Schedule
• Viral Vaccines (immunology)