Abstract | BACKGROUND:
Disc degeneration and its associated low back pain are a major health care concern causing disability with a prominent role in this country's medical, social and economic structure. Low back pain is devastating and influences the quality of life for millions. Low back pain lifetime prevalence approximates 80% with an estimated direct cost burden of $86 billion per year. Back pain patients incur higher costs, greater health care utilization, and greater work loss than patients without back pain. METHODS: Research was performed following approval of our Institutional Review Board. DNA was isolated, processed and amplified using routine techniques. Amplified DNA was hybridized to Affymetrix Genome-Wide Human SNP Arrays. Quality control and genotyping analysis were performed using Affymetrix Genotyping Console. The Birdseed v2 algorithm was used for genotyping analysis. 2589 SNPs were selected a priori to enter statistical analysis using lotistic regression in SAS. RESULTS: CONCLUSIONS: Findings contribute to the challenging field of disc degeneration and pain, and are important in light of the high clinical relevance of low back pain and the need for improved understanding of its fundamental basis.
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Authors | Helen E Gruber, Wei Sha, Cory R Brouwer, Nury Steuerwald, Gretchen L Hoelscher, Edward N Hanley Jr |
Journal | International journal of medical sciences
(Int J Med Sci)
Vol. 11
Issue 7
Pg. 748-53
( 2014)
ISSN: 1449-1907 [Electronic] Australia |
PMID | 24904231
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Catechol O-Methyltransferase
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Topics |
- Adult
- Catechol O-Methyltransferase
(genetics)
- Female
- Genetic Association Studies
- Humans
- Intervertebral Disc Degeneration
(complications, genetics, pathology)
- Low Back Pain
(complications, genetics, pathology)
- Male
- Middle Aged
- Pain
(complications, genetics, pathology)
- Polymorphism, Single Nucleotide
- Sex Characteristics
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