Abstract | BACKGROUND: Surgery is currently the sole treatment modality for anal fistulas. However, surgery is associated with complications such as permanent incontinence, which reduces quality of life. OBJECTIVE: DESIGN: Prospective single arm study. SETTING: Tertiary university hospital PATIENTS: : Adult patients with symptomatic perianal fistula presenting between June 2012 and January 2013. INTERVENTION: MAIN OUTCOME MEASURES: The primary outcome measure was the rate of complete clinical healing. RESULTS: Fifty-six consecutive patients with anal fistula were analyzed. Of those, 29 (52%) had complete clinical healing without recurrence for a median of 10 months. The median number of irrigations needed for complete clinical healing was 4 (1-10). The level of satisfaction was excellent in patients with complete clinical healing. The frequency of complaints was the only independent factor that had an impact on healing; patients with intermittent discharge had a significantly higher rate of complete clinical healing (67%) than those with continuous discharge (40%). There were no notable complications. LIMITATIONS: Short follow-up, small sample size, and no comparisons. CONCLUSION: This study demonstrates that the application of silver nitrate solution often produces a favorable outcome in the treatment of anal fistula. This method may be considered as a first-line treatment for the disease because it is simple, performed on an outpatient basis, minimally invasive, and lacks the complications encountered with current conventional surgical modalities.
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Authors | Wafi Attaallah, Davut Tuney, Bahadir M Gulluoglu, M Umit Ugurlu, Omer Gunal, Cumhur Yegen |
Journal | Diseases of the colon and rectum
(Dis Colon Rectum)
Vol. 57
Issue 7
Pg. 882-7
(Jul 2014)
ISSN: 1530-0358 [Electronic] United States |
PMID | 24901690
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Anti-Infective Agents, Local
- Silver Nitrate
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Topics |
- Administration, Topical
- Adolescent
- Adult
- Aged
- Anti-Infective Agents, Local
(therapeutic use)
- Drug Administration Schedule
- Female
- Follow-Up Studies
- Humans
- Male
- Middle Aged
- Patient Satisfaction
(statistics & numerical data)
- Prospective Studies
- Rectal Fistula
(drug therapy)
- Silver Nitrate
(therapeutic use)
- Therapeutic Irrigation
- Treatment Outcome
- Wound Healing
- Young Adult
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