Effects of 5-amino salicylic acid on the expression of multidrug resistance gene in ulcerative colitis.

Abstract

BACKGROUND/AIMS:

To study the effect of drugs on the expression of multidrug resistance gene in ulcerative colitis.

METHODOLOGY:

The expressions of multidrug resistance (MDR) 1 gene and its product P-Gp were detected by reverse transcription-polymerase chain reaction and immunohistochemistry to realize the impact of drugs on ulcerative colitis.

RESULTS:

MDR1 gene and P-Gp did not exhibit significant difference (P > 0.05) before and after amino salicylic acid drug treatment. Compared with the control group, their expressions before treatment in the ineffective corticosteroid- and immunosuppressant-treated groups did not exhibit significant difference (P > 0.05). Their pre- and post-treatment expressions in the ineffective groups were compared with those in the normal control group and in the effective group, and significant differences were observed (P < 0.05).

CONCLUSIONS:

5-Amino salicylic acid drugs have little effect on the expression of MDR1 and its product P-Gp. The expressions of MDR1 and P-Gp were much higher in groups that showed ineffectiveness for corticosteroids and immunosuppressants after treatment.

• Authors: Ying-Jian Zhang, Ping Wang, Yu Zhang, Yu-Feng Zheng, Jian-Jun Jin, Jin-Liang Wang
• Journal: Hepato-gastroenterology (Hepatogastroenterology) 2014 Mar-Apr Vol. 61 Issue 130 Pg. 367-72 ISSN: 0172-6390 [Print] Greece
• PMID: 24901142 (Publication Type: Journal Article)

Chemical References

• ABCB1 protein, human
• ATP Binding Cassette Transporter, Subfamily B
• ATP Binding Cassette Transporter, Subfamily B, Member 1
• Anti-Inflammatory Agents, Non-Steroidal
• Glucocorticoids
• Immunosuppressive Agents
• Mesalamine

Topics

• ATP Binding Cassette Transporter, Subfamily B
• ATP Binding Cassette Transporter, Subfamily B, Member 1 (biosynthesis, genetics)
• Adolescent
• Adult
• Aged
• Anti-Inflammatory Agents, Non-Steroidal (pharmacology)
• Case-Control Studies
• Colitis, Ulcerative (genetics, metabolism)
• Female
• Gene Expression (drug effects)
• Glucocorticoids (pharmacology)
• Humans
• Immunohistochemistry
• Immunosuppressive Agents (pharmacology)
• Male
• Mesalamine (pharmacology)
• Middle Aged
• Polymerase Chain Reaction
• Young Adult