Clinical Significance of F-18 FP-CIT Dual Time Point PET Imaging in Idiopathic Parkinson's Disease.

Abstract

PURPOSE:

The purpose of this study was to investigate the diagnostic value of dual time point F-18 FP-CIT PET imaging in idiopathic Parkinson's disease (PD).

MATERIALS AND METHODS:

Twenty-four patients with PD (mean age 69.6) and 18 healthy people (mean age 70.26) underwent two sequential PET/CT scans (dual time point imaging) at 90 and 210 min after F-18 FP-CIT injection. Tracer activity of region of interest was measured in the caudate, putamen and a reference region in the brain from both time points. The outcome parameter was the striatooccipital ratio (SOR). Normal SOR values were obtained in the control group. The percent change in tracer activity between 90- and 210-min images was calculated. The SOR values and the percent change in tracer activity were compared between the patients and healthy control group.

RESULTS:

The SOR values for the caudate, anterior and posterior putamen at both 90- and 210-min images were significantly reduced in the patients with PD. The lowest P value was obtained for the anterior and posterior putamen (p < 0.001) at both time points. There were significant differences of the percent change in tracer activity for the anterior and posterior putamen in the two groups (p = 0.01).

CONCLUSIONS:

F-18 FP-CIT PET scans at 90 and 210 min after injection are both able to diagnose PD. Therefore, the 90-min image by itself is sufficient for diagnosing PD.

• Authors: Jin Kyoung Oh, Ik Dong Yoo, Ye Young Seo, Yong An Chung, Ie Ryung Yoo, Sung Hoon Kim, In Uk Song
• Journal: Nuclear medicine and molecular imaging (Nucl Med Mol Imaging) Vol. 45 Issue 4 Pg. 255-60 (Dec 2011) ISSN: 1869-3474 [Print] Germany
• PMID: 24900015 (Publication Type: Journal Article)