A useful scoring system for the prediction and management of delayed graft function following kidney transplantation from cadaveric donors.

Abstract	Delayed graft function (DGF) is a common complication in kidney transplantation and is known to be correlated with short- and long-term graft outcomes. Here we explored the possibility of developing a simple tool that could predict with good confidence the occurrence of DGF and could be helpful in current clinical practice. We built a score, tentatively called DGFS, from a French multicenter and prospective cohort of 1844 adult recipients of deceased donor kidneys collected since 2007, and computerized in the Données Informatisées et VAlidées en Transplantation databank. Only five explicative variables (cold ischemia time, donor age, donor serum creatinine, recipient body mass index, and induction therapy) contributed significantly to the DGF prediction. These were associated with a good predictive capacity (area under the ROC curve at 0.73). The DGFS calculation is facilitated by an application available on smartphones, tablets, or computers at www.divat.fr/en/online-calculators/dgfs. The DGFS should allow the simple classification of patients according to their DGF risk at the time of transplantation, and thus allow tailored-specific management or therapeutic strategies.
Authors	Marion Chapal, Florent Le Borgne, Christophe Legendre, Henri Kreis, Georges Mourad, Valérie Garrigue, Emmanuel Morelon, Fanny Buron, Lionel Rostaing, Nassim Kamar, Michèle Kessler, Marc Ladrière, Jean-Paul Soulillou, Katy Launay, Pascal Daguin, Lucile Offredo, Magali Giral, Yohann Foucher
Journal	Kidney international (Kidney Int) Vol. 86 Issue 6 Pg. 1130-9 (Dec 2014) ISSN: 1523-1755 [Electronic] United States
PMID	24897036 (Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
Chemical References	Antilymphocyte Serum Immunosuppressive Agents Creatinine
Topics	Adolescent Adult Age Factors Aged Aged, 80 and over Antilymphocyte Serum (administration & dosage) Area Under Curve Body Mass Index Cadaver Child Child, Preschool Cohort Studies Cold Ischemia (adverse effects) Creatinine (blood) Decision Support Techniques Delayed Graft Function (diagnosis, etiology, therapy) Female Humans Immunosuppressive Agents (administration & dosage) Induction Chemotherapy Infant Kidney Transplantation (adverse effects) Male Middle Aged Mobile Applications Predictive Value of Tests Prospective Studies ROC Curve Risk Factors Smartphone Tissue Donors Young Adult

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